Molecular mechanisms of selective autophagy during the course of ageing

衰老过程中选择性自噬的分子机制

• 批准号: 1897957
• 金额: --
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1897957
• 关键词: Molecular; mechanisms; selective; autophagy; during

Advances in modern medicine have led to a significant increase in human life expectancy. A consequence of this has been the increase of the frequency of ageing-related diseases. Recent studies have indicated that a breakdown of the proteolytic cellular machinery of autophagy in cells, is involved in the development of ageing-related diseases. Autophagy is an essential catabolic process that involves the degradation of cytoplasmic material through the lysosomal pathway. Cells use autophagy to generate materials and energy when conditions become unfavourable. They also use this process to clear damaged cellular components. We will use the fruit fly Drosophila melanogaster as a genetically modifiable model organism to investigate the mechanisms of selective autophagy during ageing in vivo. These mechanisms are very similar between fruit flies and humans, so the results will have direct relevance to human health.

现代医学的进步大大延长了人类的预期寿命。其结果是与老龄化有关的疾病的频率增加。最近的研究表明，细胞中自噬的蛋白分解细胞机制的崩溃与衰老相关疾病的发展有关。自噬是一种重要的分解代谢过程，它通过溶酶体途径降解细胞质。当条件变得不利时，细胞利用自噬来产生材料和能量。他们也使用这一过程来清除受损的细胞成分。我们将利用果蝇作为一种可遗传修饰的模式生物来研究体内衰老过程中选择性自噬的机制。这些机制在果蝇和人类之间非常相似，因此结果将与人类健康直接相关。