Planning Grant for the New York Colon Cancer Study Group

在过去的8年里，纽约结肠癌研究小组（NYCCSG）的成员在应用基因组和遗传学方法来剖析营养素的作用以及营养素-基因相互作用在结肠癌发展中的作用方面取得了非常成功的个人和合作。在这些年里，该小组每月举行一次会议，评估文献，设计实验方法，讨论数据，并为结果的出版和资金的申请计划战略。NCI（CA-01-015）的公告促使我们探索我们计划的重大扩展，以解决NCI在营养基因相互作用领域的目标。此P20计划补助金申请提出了6个月的时间，在此期间，NYCCSG的创始成员，由阿尔伯特爱因斯坦癌症中心，相关的蒙蒂菲奥里医疗中心和斯特朗癌症预防中心的核心研究人员组成，将评估： 新的研究领域，以增加我们的广泛计划，营养-基因相互作用的风险，和进展，肿瘤的发展 阐明基因和营养物质对肿瘤调节的相互作用机制的新技术 对我们的核心合作研究者团队进行重大补充，以纳入新的研究者并与其他主要项目建立合作关系 本综述的目的是大大扩展我们关于影响风险的营养素-基因相互作用的项目。和癌症的发展，在预期的U 54应用到NCI的合作专业中心。

Over the last 8 years, members of the New York Colon Cancer Study Group (NYCCSG) have been extraordinarily successful, both individually and in collaboration, in applying genomic and genetic approaches to dissection of the effects of nutrients, and nutrient-gene interactions, in the development of colon cancer. The group has met monthly during these years to evaluate the literature, design experimental approaches, discuss data, and to plan strategies for publication of results and for application for funds. The announcement from the NCI (CA-01-015) that prompted this application has stimulated us to explore a significant expansion of our program to address the goals of the NCI in the area of nutrient-gene interactions. This P20 Planning Grant Application proposes a 6 month period during which the founding members of the NYCCSG, consisting of a core group of investigators at the Albert Einstein Cancer Center, the associated Montefiore Medical Center, and the Strang Cancer Prevention Center, will evaluate: new areas of research to add to our extensive program on nutrient- gene interactions in risk for, and progression of, tumor development new technologies to elucidate mechanisms involved in the interactive affect of genes and nutrients on tumor modulation significant additions to our core group of collaborating investigators to incorporate new investigators and establish collaborations with other major programs program infrastructure The goal of this review is a substantial broadening of our program on nutrient-gene interactions that influence risk. and the development of cancer, in anticipation of a U54 application to the NCI for a Cooperative Specialized Center.