Hollings Cancer Center Planning Grant

霍林斯癌症中心（HCC）是南卡罗来纳州医科大学癌症活动的重点。MUSC是该州医疗保健专业人员的主要生产者，并通过其附属教学医院提供三级和四级医疗资源。每年用于校园癌症相关研究的资金总额约为4300万美元。自1993年目前的HCC设施开放以来，临床数量几乎增加了两倍。为了满足这些需求，MUSC承诺投资3990万美元建造一座相邻的七层133，000平方英尺的塔楼。破土动工将于2001年夏天进行。总部合同委员会面临独特的情况和挑战。南卡罗来纳州有一个大的农村，服务不足，非洲裔美国人的比例很高，几种癌症（前列腺，口腔，宫颈和食管）的癌症死亡率很高。这些和其他需求表明，一个国家癌症研究所指定的综合癌症中心，以服务于南卡罗来纳州以及该地区的关键必要性。已开发了三个主要的基础科学项目：1）癌症生物学（信号转导和细胞凋亡），2）功能遗传学，3）基础和临床前治疗学。该P20补助金申请额外发展的目标领域是转化研究计划，以补充强大的临床多学科小组，并将基础科学的发现与临床领域联系起来。在健康、预防和控制方面开展了新的活动，重点关注南卡罗来纳州公民的特殊需要（遗传、环境和行为问题和障碍;早期发现项目;癌症健康结果研究）。一个移动的卫生单位、非洲裔美国人接入网络和远程卫生方案将被用来研究南卡罗来纳州与癌症有关的需求和兴趣。P20奖将使HCC更好地实现其目标，为该阶段的所有公民开发全面的癌症治疗方案;创造一个从基本概念到临床干预的癌症研究环境;并减少农村的癌症负担，服务不足的人口。

The Hollings Cancer Center (HCC) is the focus of cancer activities at the Medical University of South Carolina. MUSC is the major producer of healthcare professionals in the State and a tertiary and quaternary medical resource via its affiliated teaching hospital. Funding for cancer-related research on campus totals about $43 million per year. Clinical volume has nearly tripled since the present HCC facility opened in 1993. To meet these needs, MUSC has committed $39.9 million to build an adjacent seven-story 133,000 square foot tower. Groundbreaking will occur summer of 2001. Unique circumstances and challenges face HCC. South Carolina has a large rural, underserved, high percentage African-American population and high cancer mortality rates in several cancers (prostate, oral, cervical and esophageal). These and other needs demonstrate the critical necessity for an NCI-designated comprehensive cancer center to serve South Carolina as well as the region. Three major basic science programs have been developed: 1) Cancer Biology (signal transduction and apoptosis), 2) Functional Genetics, and 3) Basic and Preclinical Therapeutics. A targeted area on additional development for this P20 grant application is a Translational Research Program to complement the strong clinical multi-disciplinary groups and bridge the discoveries in basic science to the clinical area. New activities have been initiated in Wellness, Prevention and Control that focus on particular needs of South Carolina citizens (genetic, environmental and behavioral issues and barriers; early detection projects; and cancer health outcomes research). A mobile health unit, African-American access network, and telehealth programs will be utilized to research out to the South Carolinians with cancer-related needs and interest. A P20 award will better position HCC to fulfill its goals to develop comprehensive cancer treatment options for all the citizens of the stage; create an environment where cancer research will be fostered from basic concept to clinical intervention; and reduce the cancer burden in a rural, underserved population.