CORE--PET FACILITIES

PET设施核心将协调初始 正电子发射计算机断层扫描、临床和CT数据的获取、重建和存档 在四个项目之间共享的。鲍尔斯博士将担任总干事 这个核心。所有的PET研究都将在西门子961 ECAT Exact HR上进行 47型PET扫描仪，位于#年的神经危重护理PET研究机构 神经科神经外科重症监护室。这个设施是 致力于科学研究，对一种可爱的脑损伤进行研究 当务之急。它配备了所有的生命维持设备 可在NNICU的其他地方使用。目前，所有氧气-15 进行PET测量所需的放射性药物有 在华盛顿大学医学中心回旋加速器设施中准备 周一至周五上午7点至17点由训练有素的操作员提供服务。在……里面 为顺利招收急性颅脑损伤患者 对于项目1和项目2，将需要延长工作时间 目前正在工作的外部神经危重护理PET研究机构 几个小时。在第一年，我们将建立一个串联的交付系统 目前在RAST建筑成像中运行的级联加速器 两个街区外的中心。这一系统将为研究提供灵活性 患者在非工作时间不需要回旋加速器操作员。每个人 在四个项目中，涉及获取和记录临床和 创伤性脑损伤患者的诊断实验室信息 和脑内出血。在我们的初步研究中，我们使用了 为此目的手工填写的数据表。在第一年，我们将 继续使用我们的纸质数据表单收集数据。这将使我们能够 获取数据收集经验并修改表格 从而提高精确度和效率。这些修订和 修改后的表单将作为修改现有 计算机化数据库系统将在第二年实施。修改 和这个临床数据库的实施，以满足这一需求 计划项目应提供效率方面的改进， 数据收集和检索的标准化和完整性。

The PET Facilities Core will co-ordinate those aspects of the initial acquisition, reconstruction and archiving of the PET, clinical and CT data that are shared among the four projects. Dr. Powers will the Director of this Core. All PET studies will be done on the Siemens 961 ECAT EXACT HR 47 PET scanner located in the Neurocritical Care PET Research Facility in the Neurology Neurosurgery Intensive Care Unit. This facility is dedicated to scientific research with studies of a cute brain injury given top priority. it is outfitted with al the life support equipment available elsewhere in the NNICU. Currently, all oxygen-15 radiopharmaceuticals necessary for performance of the PET measurements are prepared in the Washington University Medical Center Cyclotron Facility staffed by trained operators from 0700-1700, Monday through Friday. In order to successfully recruit patients with acute traumatic brain injury for Projects 1 and 2, it will be necessary to expand working hours of the Neurocritical Care PET Research Facility outside the current working hours. In year 1, we will construct a delivery system from a Tandem Cascade Accelerlator currently operating in the Rast Building Imaging Center two blocks away. This system will provide the flexibility to study patients during off-hours without the need for a cyclotron operator. Each of the four projects involves acquisition and recording of clinical and diagnostic laboratory information on patients with traumatic brain injury and intracerebral hemorrhage. In our preliminary studies we have used data sheets filled out by hand for this purpose. During year 1, we will continue to use our paper data forms to collect data. This will allow us to gain experience with the data collection and modify the forms accordingly to improve accuracy and efficiency. These revised and modified forms will serve as the basis for modifications to an existing computerized database system to be carried out in year 2. Modification and implementation of this clinical database to serve th needs of this program project should provide improvement in the efficiency, standardization and integrity of data collection and retrieval.