IMMUNOPATHOLOGY OF HIV-1 VPR

HIV-1 VPR 的免疫病理学

• 批准号: 6496565
• 负责人: VELPANDI AYYAVOO
• 金额: $ 29.6万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6496565
• 关键词: CD4 molecule; CD8 molecule; HIV infections; T lymphocyte; antigen presenting cell; cell population study; chromatography; host organism interaction; human immunodeficiency virus 1; immunogenetics; immunologic techniques; immunopathology; immunoregulation; intermolecular interaction; microorganism immunology; molecular site; protein engineering; protein structure function; recombinant proteins; reporter genes; statistics /biometry; virus genetics; virus infection mechanism; virus protein

DESCRIPTION (provided by applicant): The central objective of this project is to understand the role of Vpr in HIV-1 immunopathogenesis and disease progression. The Applicant proposes to evaluate the mechanisms of Vpr-mediated regulation of CD4+ T cell and macrophage responses, and to assess the possibility that Vpr modulates the in vivo immune response to viral infection. Specifically, the research team will: (1) investigate the direct effects of Vpr on antigen presenting cells and T cells in vitro; (2) determine the extent to which Vpr mediates immune dysregulation using an in vitro immunization model; (3) identify the domains of Vpr involved in mediating these immune functions using Vpr mutants. The proposed studies will lead to an understanding of how Vpr modulates basic cellular events in these important immune cell types and how it may regulate immune functions in vitro and in vivo.

描述（由申请人提供）：该项目的核心目的是 了解VPR在HIV-1免疫致病发生和疾病中的作用 进展。申请人建议评估VPR介导的机制 调节CD4+ T细胞和巨噬细胞反应，并评估 VPR调节体内免疫反应对病毒感染的可能性。 具体而言，研究小组将：（1）研究VPR的直接影响 在体外抗原呈递细胞和T细胞上； （2）确定 VPR使用体外免疫模型介导免疫失调； （3）确定介导这些免疫功能的VPR的域 使用VPR突变体。拟议的研究将导致对如何理解 VPR调节这些重要的免疫细胞类型中的基本细胞事件， 它如何在体外和体内调节免疫功能。