PREVALENCE AND PROGRESSION OF DM2 RISK IN MA YOUTH

MA 青年中 DM2 风险的患病率和进展

• 批准号: 6517862
• 负责人: DANIEL ESTEN HALE
• 金额: $ 32.63万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-01 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6517862
• 关键词: Hispanic Americans; acanthosis nigricans; adolescence (12-20); blood tests; child physical development; clinical research; comorbidity; disease /disorder proneness /risk; fasting; gender difference; glucose; glucose tolerance test; high risk behavior /lifestyle; homeostasis; human subject; hyperinsulinism; insulin; interview; longitudinal human study; middle childhood (6-11); noninsulin dependent diabetes mellitus; pathologic process; pediatrics; questionnaires; statistics /biometry

Over the past 5 years there have been reports of type 2 diabetes (DM2) in minority children in the U.S., including Mexican Americans (MA). Locally, in the past 3 years more MA children were seen with DM2 than type 1 diabetes (DM1), although the incidence of DM1 has not decreased. While the high prevalence and rising incidence of DM2, related risk factors and co-morbidities in MA adults is extensively documented, minimal information is available on the prevalence or incidence of these problems in MA children who share the same genetic heritage and live in the same environment. Even less is known about the natural progression from genetic risk to overt disease in children. Therefore, the specific aims of this proposal are to: 1. Determine the prevalence of risk factors, hyperinsulinism, impaired fasting glucose and diabetes in a homogenous group of approximately 2000 MA children 4th grade, 9 and 10 years of age) (Phase 1) 2. Explore the relationship between risk factors and glucose homeostasis abnormalities in approximately 300 MA children using a detailed clinical assessment and extensive biochemical investigations. The children will be in 3 subsets: impaired fasting glucose, high-risk, and low risk. (Phase 2). 3. Examine the temporal change in physical and biochemical parameters in the 3 subsets over 4-years (Phase 3). Children will be seen annually, because this is a period of dynamic physical change. Completion of the proposed studies will provide an estimate of the prevalence of glucose homeostasis abnormalities in MA children, increase understanding of the metabolic abnormalities at a relatively early age and stage, permit an examination of the natural progression of these abnormalities, and provide an assessment of the applicability of the new American Diabetes Association guidelines for screening MA children.

在过去的5年里，美国有少数民族儿童患2型糖尿病（DM2）的报道，墨西哥裔美国人（MA） 在当地，在过去的3年中，更多的MA儿童被认为是DM 2比1型糖尿病（DM 1），虽然DM 1的发病率并没有下降。 虽然广泛记录了MA成人中DM 2、相关风险因素和合并症的高患病率和发病率上升，但关于具有相同遗传遗传和生活在相同环境中的MA儿童中这些问题的患病率或发病率的信息很少。 对于儿童从遗传风险到显性疾病的自然发展过程，我们所知更少。 因此，本提案的具体目标是：1.确定风险因素、高胰岛素血症、空腹血糖受损和糖尿病在约2000名MA儿童（4年级、9岁和10岁）的同质组中的患病率（第1阶段）2。通过详细的临床评估和广泛的生化研究，探讨约300例MA儿童中危险因素与葡萄糖稳态异常之间的关系。 这些儿童将分为3个亚组：空腹血糖受损、高风险和低风险。 （第二阶段）。3.检查4年内3个亚组的物理和生化参数的时间变化（第3阶段）。 每年都会看到孩子们，因为这是一个充满活力的身体变化时期。完成拟议的研究将提供MA儿童中葡萄糖稳态异常的患病率估计，增加对相对早期年龄和阶段的代谢异常的理解，允许检查这些异常的自然进展，并提供新的美国糖尿病协会指南筛查MA儿童的适用性评估。