CLONING THE POLAR LETHAL OVUM MUTANT GENE OF THE MOUSE

描述(改编自调查人员摘要)：当DDK的女性 近交系小鼠与许多其他近交系的雄性交配， 大多数胚胎在植入前发育过程中死亡。这个 其他近交系的DDK雄性和雌性之间的相互交配是 完全可行。这种致命特征的母性和父性成分 分离为两个紧密连锁的基因座。在过去的三年里，我们有 成功地将这些基因定位到一个小区域(大约300个 Kb)。这些基因的分离应该允许 确定母方和父方基因如何相互作用，从而导致 植入前胚胎的死亡，以及这种相互作用可能如何导致 11号染色体的优先分离(减数分裂驱动) 杂合子的雌性。这些基因的分离也将使 关于非孟德尔血统、父母血统依赖、传播的研究 这一特点的实现。

DESCRIPTION (Adapted from investigator's abstract): When females of the DDK inbred mouse strain are mated to males of many other inbred strains, the vast majority of the resulting embryos die during preimplantation development. The reciprocal matings, between DDK males and females of other inbred strains are fully viable. The maternal and paternal components of this lethal trait segregate as two closely-linked loci. Over the last three years, we have succeeded in localizing these genes to a small area (approximately 300 kilobases) of mouse chromosome 11. The isolation of these genes should allow a determination of how the maternal and paternal genes interact to result in the death of preimplantation embryos and, perhaps, how this interaction results in the preferential segregation of chromosomes 11 (meiotic drive) among heterozygous females. The isolation of these genes will also allow an investigation of how the non-Mendelian, parental-origin dependent, transmission of this trait is achieved.