The mechanisms of the RNA-binding proteins LARP4A and LARP4B in cancer cell migration and proliferation

RNA结合蛋白LARP4A和LARP4B在癌细胞迁移和增殖中的机制

• 批准号: 1930663
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1930663
• 关键词: mechanisms; RNA; binding; proteins; LARP4A

The primary research question in this project is to investigate the function of the LARP4A/B RNA-binding proteins in cancer cell invasion and metastasis. RNA-binding proteins are ubiquitous proteins and deregulated expression can contribute to cancer development by altering the stability and translation of RNA transcripts. LARP4A and 4B proteins are novel regulators of cancer migration and invasion, however, their specific mRNA targets and mechanism of action are not known and they exhibit differential binding to mRNA domains. The hypothesis being tested is that LARP4A and LARP4B regulate cell morphology, migration and proliferation of carcinoma and sarcoma cells, and have distinct roles and targets in the modulation of these processes.

本课题的主要研究内容是探讨LARP 4A/B RNA结合蛋白在肿瘤细胞侵袭和转移中的作用。RNA结合蛋白是普遍存在的蛋白质，并且表达失调可以通过改变RNA转录物的稳定性和翻译而促进癌症发展。LARP 4A和4 B蛋白是癌症迁移和侵袭的新型调节剂，然而，它们的特异性mRNA靶点和作用机制尚不清楚，并且它们表现出与mRNA结构域的差异结合。正在测试的假设是LARP 4A和LARP 4 B调节癌和肉瘤细胞的细胞形态、迁移和增殖，并且在这些过程的调节中具有不同的作用和靶点。