Identifying novel targets for treating pain in Parkinson's disease by unravelling the neuroimmune contribution.

通过揭示神经免疫的贡献来确定治疗帕金森病疼痛的新靶标。

• 批准号: 1931742
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1931742
• 关键词: Identifying; novel; targets; treating; pain

The overall objective of this project is to investigate the cellular and molecular mechanisms underlying pain in Parkinson's disease. Specifically, we hypothesise that microglial activation in descending pathways from the brain modulates pain signalling at the spinal cord level and contributes to neuroinflammation-driven pain in Parkinson's. This collaboration between pre-clinical experts in Parkinson's (Dr Duty) and pain (Professor Malcangio) and leading clinical expert in pain in Parkinson's (Professor Chaudhuri) aims to find novel analgesic targets for better treating pain in Parkinson's patients.

本项目的总体目标是研究帕金森病疼痛的细胞和分子机制。具体来说，我们假设，小胶质细胞激活下行通路从大脑调节疼痛信号在脊髓水平，并有助于神经炎症驱动的疼痛在帕金森氏症。帕金森氏症（Duty博士）和疼痛（Malcangio教授）的临床前专家与帕金森氏症疼痛（Chaudhuri教授）的领先临床专家之间的合作旨在寻找新的镇痛靶点，以更好地治疗帕金森氏症患者的疼痛。