UAMS Alzheimer's Disease Core Center

阿肯色州医学大学(UAMS)提议建立一个阿尔茨海默病核心中心(ADCC)，其使命是提供共享资源，在国际上促进和加强阿尔茨海默病。它将汇集来自不同学科的研究科学家和教育工作者的干部，包括老年病学、神经病学、神经病理学、护理学、放射学、老年药理学、老年心理学和卫生服务研究。在本申请中申请的ADCC资源将维持和加强老年病部目前国际公认的AD研究计划，其中包括开发早期检测标记物和确定AD发病机制炎症机制治疗干预目标的基础研究；确定和实施促进AD老年人功能独立性和减少问题行为的策略的临床研究；以及确定AD患者及其照顾者使用服务的预测因素的医疗服务研究，以及在确定诊断痴呆症时这种使用对初级保健提供者的影响。行政核心将通过促进在关键AD问题上扩大跨学科合作来促进AD研究。临床核心将通过纵向评估一组患有痴呆症和对照组的老年人，包括来自不同文化背景的个人，重点是农村和非裔美国人，来刺激AD研究。神经病理学核心将通过将临床特征良好的患者材料与尸检数据相关联，为基础和临床研究做出贡献。教育核心将向专业人员、患者和家庭，特别是非洲裔美国人和农村社区的家庭传播AD信息。UAMS在AD研究方面的优势将使ADCC能够调查AD的发展、身体和行为影响以及社会影响。该ADCC将通过神经病理学的基础研究、功能表现和问题行为的临床研究以及检查获取和利用问题的卫生服务研究，致力于预防和早期发现AD，从而为国家老龄研究所和阿尔茨海默氏症协会的总体目标做出贡献。

The University of Arkansas for Medical Sciences (UAMS) proposes to establish an Alzheimer's Disease Core Center (ADCC) with the mission of providing a shared resource to facilitate and enhance Alzheimer's disease internationally. It will bring together a cadre of research scientists and educators from a variety of disciplines, including geriatrics, neurology, neuropathology, nursing, radiology, geropharmacology, geropsychology, and health service research. ADCC resources requested in this application will sustain and strengthen the Department of Geriatric's current internationally-recognized AD research programs, which including basic research to develop early detection markers and to identify targets for therapeutic interventions of inflammatory mechanisms in AD pathogenesis; clinical research to identify and implement strategies that promote functional independence and decrease problem behaviors among older adults with AD, and health services research to identify predictors of service use among AD patients and their caregivers and the impact of this use on primary care providers when determining the diagnosis of dementia. The Administrative Core will advance AD research by stimulating expanded interdisciplinary collaboration on critical AD questions. The Clinical Core will stimulate AD research by longitudinally assessing a cohort of older adults with dementia and controls, including individuals from diverse cultural backgrounds with an emphasis on rural and African-American adults. The Neuropathology Core will contribute to both basic and clinical research by correlating clinically well-characterized patient material with post-mortem data. The Education Core will disseminate AD information to professionals, patients and families, particularly those in African- American and rural communities. The strengths in AD research at UAMS will allow the ADCC to investigate the development, physical and behavioral effects and social impact of AD. This ADCC will contribute to the overall goals of the National Institute on Aging and the Alzheimer's Association by focusing on prevention and early detection of AD through basic research in neuropathology, clinical research on functional performance and problem behaviors, and health services research examining issues of access and utilization.