A Device to Treat Bradykinesia in Parkinson's Disease

治疗帕金森病运动迟缓的装置

• 批准号: 6444375
• 负责人: PHILLIP E GESOTTI
• 金额: $ 10万
• 依托单位: SENTEL CORPORATION
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-20 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6444375
• 关键词: Parkinson's disease; abnormal involuntary movement; biomedical equipment development; clinical biomedical equipment; clinical research; conditioning; human subject; motor neurons; neuromuscular stimulator; neurophysiology; substantia nigra

DESCRIPTION (provided by applicant): This proposal evaluates a prototype Transcutaneous Electrical Movement Timing Stimulator (TEMTS) with the potential to improve akinesia/ bradykinesia in Parkinson?s Disease (PD). We will evaluate improvements through a randomized sham versus actual 20 patient clinical study with each human subject as its own control, utilizing a battery of quantitative motor performance tests and instrumentation. TEMTS could significantly enhance everyday task performance, such as, walking, cooking, eating, personal hygiene and exercise, improving the quality of life for the 1.2 million people in the U.S. affected by PD. PD is characterized by movement dysfunction resulting from selective neurodegeneration of dopamine producing neurons of the substantia nigra pars compacta (SNpc). Promisingly, the dysfunction appears to be pharmacologic resulting in reversible physiologic abnormalities. The common scenario of ?paradoxical kinesia?, where PD patients can move normally with correct external sensory cueing, is empirical evidence of even advanced PD patients exhibiting ability to produce normal movements. We have produced and demonstrated in a case study, a sensory cueing device that normalizes many of these PD motor deficits. This proposal evaluates TEMTS performance in a statistically significant patient population and evolves the design to improve efficacy leading to an alternative treatment for PD motor dysfunction.

描述（由申请人提供）：本提案评价了一种原型经皮电运动定时刺激器（TEMTS），该刺激器有可能改善帕金森病患者的运动不能/运动迟缓？疾病（PD）。我们将通过一项随机化假手术与实际20例患者临床研究来评估改善情况，其中每例人类受试者作为其自身对照，使用一组定量运动性能测试和仪器。TEMTS能显著提高日常任务表现，如步行、烹饪、进食、个人卫生 和运动，改善美国120万受PD影响的人的生活质量。PD的特征在于由黑质丘脑部（SNpc）的产生多巴胺的神经元的选择性神经变性引起的运动功能障碍。有希望的是，功能障碍似乎是药理学导致可逆的生理异常。常见的场景是？反常运动症？其中PD患者可以在正确的外部感觉提示下正常移动，这是甚至晚期PD患者也表现出产生正常运动的能力的经验证据。我们已经生产并证明在一个案例研究中，感觉提示设备，正常化许多这些PD运动缺陷。该提案在具有统计学意义的患者人群中评估了TEMTS性能，并改进了设计， 有效性导致PD运动功能障碍的替代治疗。