Local Profound Hypothermia in Intracranial Hemorrhage

描述（由申请人提供）：在大多数出血性卒中中， 血管可能出血进入脑组织，产生颅内出血（ICH）。 血凝块的存在会刺激脑组织，引起局部缺血， 坏死和水肿。目前，对A型糖尿病患者的治疗方法很少。 患者ICH。低温治疗与全身低温治疗一样， 不切实际并且涉及显著的并发症。我们建议使用本地的， 深度低温（15-18 ℃）来测试这种ICH损伤。这涉及 通过钻孔放置冷却装置， 脑出血附近的大脑达到深度低温水平。ICH发生在约85，000 在美国，每年有58%的患者死亡， 30天，而大多数幸存者遭受严重的神经功能缺损。在 第一阶段，原型器械将在体外设计、制造、测试并用于 ICH的猪动物模型以测试有效性。功能评估， 将使用组织学测量以及成像方法。临床 在实践中，该设备将允许治疗脑叶中的ICH患者。 脑出血，约占所有非物质文化遗产的40%。

DESCRIPTION (provided by applicant): In most hemorrhagic strokes, cerebral vessels may bleed into brain tissue producing an intracranial hemorrhage (ICH). The presence of clot causes irritation of brain tissue, causing ischemia, necrosis, and edema. Currently, there is very little treatment available to a patient with ICH. Hypothermia treatment, as with whole body hypothermia, is impractical and involves significant complications. We propose to use local, profound hypothermia (15-18 C) to teat such ICH insults. This involves placement of a cooling device through a burr hole and coolinga local region of brain near the ICH to profound hypothermia levels. ICH occurs in about 85,000 cases in the US annually with poor outcomes: 58 percent of patients die within 30 days, while the majority of survivors suffer major neurological deficits. In Phase I, prototype devices will be designed, built, tested in vitro and used in a porcine animal model of ICH to test for efficacy. Functional assessment, histological measurements as well as imaging methods will be used. In clinical practice, the devices would allow for treatment of ICH patents in lobar hemorrhages, which make up about 40 percent of all ICH.