Modern Design Software for Biomedical Devices

ResearchSouth正在提议研究和开发新的生物计算技术，该技术将使基于CFD的生物医学设备的自动设计优化成为可能。拟议的项目将开发创新的软件，将航空航天优化方面的最佳技术与心血管设备开发方面的技术相结合。要约人的初步工作证明了这种设计方法在应用于新的和现有的旋转式心脏辅助装置时的有效性。我们期望这一项目能够为分析和优化血液溶血和血栓形成方面的生物医学设备提供合理的基础。在第一阶段，我们将使用自动形状优化来最大限度地减少血液透析连接器中的血液溶血，并通过实验验证结果，我们将开始设计和开发基于CFD的下一代设计优化软件。在第二阶段，将采用专门为设计和分析载血设备而定制的方便用户的商业质量的软件包。建议的商业应用：该设计软件的潜在用户包括任何从事生物医学设备开发的个人、团体或公司。我们的软件将是第一个将实际血液损伤模型整合到生物医疗设备分析和设计应用程序中的商业产品。在该项目中开发的大多数设计优化软件工具将立即应用于航空航天、汽车和透平机械领域。

ResearchSouth is proposing research and development of new biocomputing technology that will enable automated CFD-based design optimizing of biomedical devices. The proposed project will develop innovative software that combines the best technologies available in aerospace optimization with those in cardiovascular device development. Preliminary work by the offerors has demonstrated the effectiveness of such a design approach when applied to new and existing rotary cardiac- assist devices. We anticipate this project to provide a rational basis for analyzing and optimizing biomedical devices with respect to blood hemolysis and thrombosis. In Phase I, we will use automated shape optimization to minimize blood hemolysis in a hemodialysis connector and experimentally validate the results, and we will begin the design and development of next-generation CFD-based design optimization software. In Phase II, a user-friendly commercial-quality software package specifically customized for design and analysis of blood- carrying devices will be implemented. PROPOSED COMMERCIAL APPLICATIONS: The potential users of this design software include any individual, group, or company engaged in biomedical device development. Our software will be the first commercial product to incorporate practical blood damage models for biomedical device analysis and design applications. The majority of the design optimization software tools developed in this project will find immediate application in the aerospace, automotive, and turbomachinery fields.