How do gut bacteria strains boost our immune system? (JUGE_Q17DTPR)

肠道细菌菌株如何增强我们的免疫系统？

• 批准号: 1937649
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1937649
• 关键词: How; do; gut; bacteria; strains

Gut bacteria are major players of human health and disease. Numerous studies have shown correlations between the gut microbiota composition and an ever-growing list of human diseases. However, the molecular mechanisms underpinning the interaction of gut commensal bacteria with the host remain ill-defined, limiting meaningful interventions to restore microbial balance. The objectives of the proposed PhD studentship project are to determine the impact of bacterial adhesins on the host immune response of Lactobacillus reuteri strains in the mammalian gastrointestinal tract. It is expected that the results from this PhD project will pinpoint molecular determinants important for retention and immunomodulatory properties of L. reuteri in the gut. This knowledge is key to the design and/or selection of probiotic strains with the required specificities.

肠道细菌是人类健康和疾病的主要参与者。许多研究表明，肠道微生物群组成与不断增长的人类疾病清单之间存在相关性。然而，支持肠道细菌与宿主相互作用的分子机制仍然不明确，限制了恢复微生物平衡的有意义的干预措施。本博士研究生项目的目标是确定细菌粘附素对哺乳动物胃肠道中罗伊氏乳杆菌菌株宿主免疫反应的影响。预计该博士项目的结果将确定对L.肠内罗伊氏菌这种知识是设计和/或选择具有所需特异性的益生菌菌株的关键。