用于缺血性心脏病 MRI 的“磁性铊”-猫眼课题宝

用于缺血性心脏病 MRI 的“磁性铊”

批准号：

6499009

负责人：

Phillip Harnish

金额：

$37.34万

依托单位：

EAGLE VISION PHARMACEUTICAL CORPORATION

依托单位国家：

美国

项目类别：

财政年份：

1999

资助国家：

美国

项目状态：

已结题

起止时间：

1999-08-01 至 2003-01-31

来源：

https://reporter.nih.gov/project-details/6499009

关键词：

bioimaging /biomedical imaging calcium ion cardiography contrast media diagnosis design /evaluation gluconate image enhancement laboratory rat magnetic resonance imaging manganese myocardial ischemia /hypoxia noninvasive diagnosis pharmacokinetics rapid diagnosis swine technology /technique development

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DESCRIPTION (Applicant's abstract verbatim): Phase I confirmed the feasibility of EVP 1001-1 to be the "thallium for magnetic resonance imaging" (MRI). Results demonstrated high levels of vascular enhancement, rapid myocardial uptake, optimal pharmacokinetics, unique imaging properties and preliminary safety. Additional results since Phase I suggest excellent utility for inducible myocardial ischemia based on enhancement patterns from EVP 1001-1 under rest and stress conditions. Phase II will extend these safety and efficacy results to clinically relevant models of ischemic heart disease (IHD) and optimize the preparation of future supplies. Upon completion, this agent will be ready for human development. EVP 1001-1 makes optimal use of the powerful potential of MRI for the diagnosis and treatment planning of IHD, with the potential to replace more limited, costly and invasive tests. PROPOSED COMMERCIAL APPLICATION: Not Available

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