Stereoretentive enantioconvergent synthesis

本项目将在实验上建立一个不对称合成的新概念：立体保留对映会聚催化。该项目将建立一种概念上新的立体保留二聚化方法，该方法可使起始物料的两种对映体均掺入产品中，而无需进行去外消旋化。几种方法将被追求证明的原则，并在复杂的天然和非天然产物的合成中的应用，然后将被用来证明在目标导向合成的立体保留-对映收敛催化的潜力。

This project will experimentally establish a new concept in asymmetric synthesis: stereoretentive enantioconvergent catalysis. This project will establish a conceptually new stereoretentive-dimerisation approach that results in both enantiomers of the starting material being incorporated into the product with no deracemisation required. Several approaches will be pursued to demonstrate proof-of principle, and applications in the synthesis of complex natural and unnatural products will then be used to demonstrate the potential of stereoretentive-enantioconvergent catalysis in target-orientated synthesis.