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ACTIVE ROLE FOR THE PERITONEAL FLUID IN THE DEVELOPMENT OF ENDOMETRIOSIS

ACTIVE ROLE FOR THE PERITONEAL FLUID IN THE DEVELOPMENT OF ENDOMETRIOSIS
腹膜液在子宫内膜异位症发展中的积极作用
批准号：
6564752
负责人：
Sampath Parthasarathy
金额：
$16.54万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
项目状态：
已结题
起止时间：
2001-12-01 至 2002-11-30
来源：
https://reporter.nih.gov/project-details/6564752
关键词：
clinical research colony stimulating factor disease /disorder etiology endometriosis endometrium estradiol female human subject immunocytochemistry interleukin 1 low density lipoprotein macrophage monocyte chemoattractant protein 1 oxidation oxidizing agents pathologic process peritoneal fluid tissue /cell culture western blottings

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Description: The major focus of Project II is the analysis of oxidized lipids and oxidized LDL in peritoneal fluid (PF) of women with endometriosis and those who do not show evidence of this disorder. The underlying hypothesis is that these oxidized products and other products generated by interaction of oxidized lipids with proteins serve as mediators for the recruitment of leukocytes into the peritoneal cavity and for the production of inflammatory cytokines and growth factors. These factors are thought to stimulate proliferation of endometrial cells. The generation of oxidized products is suggested to adversely affect sperm/egg interactions and to account for infertility in women with endometriosis.
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Role of aldehyde oxidation in atherosclerosis
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  • 负责人：
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  • 依托单位：
    UNIVERSITY OF CENTRAL FLORIDA
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  • 依托单位：
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BMP-7 induced Macrophage Polarization in Atherosclerosis
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