ACTIVE ROLE FOR THE PERITONEAL FLUID IN THE DEVELOPMENT OF ENDOMETRIOSIS

腹膜液在子宫内膜异位症发展中的积极作用

• 批准号: 6564752
• 负责人: Sampath Parthasarathy
• 金额: $ 16.54万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6564752
• 关键词: clinical research; colony stimulating factor; disease /disorder etiology; endometriosis; endometrium; estradiol; female; human subject; immunocytochemistry; interleukin 1; low density lipoprotein; macrophage; monocyte chemoattractant protein 1; oxidation; oxidizing agents; pathologic process; peritoneal fluid; tissue /cell culture; western blottings

Description: The major focus of Project II is the analysis of oxidized lipids and oxidized LDL in peritoneal fluid (PF) of women with endometriosis and those who do not show evidence of this disorder. The underlying hypothesis is that these oxidized products and other products generated by interaction of oxidized lipids with proteins serve as mediators for the recruitment of leukocytes into the peritoneal cavity and for the production of inflammatory cytokines and growth factors. These factors are thought to stimulate proliferation of endometrial cells. The generation of oxidized products is suggested to adversely affect sperm/egg interactions and to account for infertility in women with endometriosis.

描述：项目II的主要重点是氧化脂质的分析 子宫内膜异位症妇女腹腔液（PF）中氧化LDL的水平， 那些没有表现出这种疾病的证据的人。潜在的假设是 这些氧化产物和其他产物是由 氧化脂质与蛋白质作为介质的招聘， 白细胞进入腹腔并产生炎性 细胞因子和生长因子。这些因素被认为会刺激 子宫内膜细胞增殖。氧化产物的生成是 建议对精子/卵子的相互作用产生不利影响， 子宫内膜异位症的治疗方法