Industrialisation of platform chemical production from waste biomass using diverse yeast strains (WALDRON_F17ICASE1)

酵母和生物精炼过程密切相关。食品研究所拥有生物精炼中心和NCYC，沿着UEA使NRP在该领域开展尖端研究的独特地位。该生物精炼厂在开发方法方面有着良好的记录，通过使用物理、生物化学和化学途径分解植物结构，最大限度地利用农业食物链生物质。NCYC独特的超过4000种酵母菌株的集合涵盖了目前几乎未开发的大量生物多样性。最近对大约900个NCYC菌株进行的基因组测序为我们提供了独特的机会，可以筛选这些菌株的生物工业重要性状，并将其与集合中的遗传变异联系起来。学生将使用各种酵母菌株和真实的世界废弃生物质，以确定给定产品的最佳预处理，发酵工艺和酵母菌株。然后将外推代谢组学途径，并从基因组数据集建立性状信息。这项研究将涉及与工业生物精炼合作伙伴Vireol的合作，学生将在整个项目中工作。

Yeasts and biorefinery processes are intimately linked. The Institute of Food Research hosts both the Biorefinery Centre and the NCYC which, along with the UEA make the NRP uniquely placed to carry out cutting edge research in this area. The biorefinery has a track record of developing approaches to maximise the exploitation of agri-food chain biomass through the disassembly of plant structures using physical, biochemical and chemical routes. The NCYC's unique collection of over 4000 yeast strains covers a large biodiversity which is currently virtually untapped. The recent genome sequencing of around 900 NCYC strains gives us the unique opportunity to screen these strains for bio-industrially important traits and link those to the genetic variation within the collection. The student will work with both varied yeast strains and also real world waste biomass in order to ascertain the best pre-treatments, fermentation processes and yeast strains for a given product. The metabolomics pathways will then be extrapolated and trait information established from the genomic datasets. This research will involve collaboration with an industrial biorefining partner Vireol with which the student will work throughout the project.