CORE--BEHAVIOR

行为核心的目的是通过定量评估感觉运动和认知行为终点，评估大鼠和小鼠创伤性脑损伤后神经回路的功能状态。设计的范例旨在评估与流体冲击性脑损伤相关的大鼠神经行为缺陷，并控制小鼠的皮质冲击，并在可能的情况下评估神经行为终点与神经病理、神经生理和分子标志物之间的关系。核心中使用的感觉运动整合和认知测试已被证明对这些颅脑损伤模型产生的损伤敏感，这些损伤模型在中到重度损伤程度时，在顶颞叶皮质、海马体和丘脑以及白质产生明显的病理。

The purpose of the behavioral core is to evaluate the functional status of neural circuitry following traumatic brain injury in rats and mice, by quantitatively assessing sensorimotor and cognitive behavioral endpoints. Paradigms are designed to assess neurobehavioral deficits associated with fluid percussive TBI in rats, and controlled cortical impact in mice, and to evaluate, when possible, the relation between neurobehavioral endpoints and neuropathological, neurophysiological, and molecular markers. The tests of sensorimotor integration and cognition used in the core have been demonstrated to be sensitive to insults produced by these TBI models, which, at moderate to severe levels of injury severity, produce overt pathology in the pariototemporal cortex, hippocampus and thalamus, and white matter.