Formation and maintenance of chromatin domains in C. elegans

线虫染色质结构域的形成和维持

• 批准号: 1942990
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1942990
• 关键词: Formation; maintenance; chromatin; domains; C.

Genome function is partially controlled by the chromatin states underlying genomic elements. Due to technological developments over the last decade, it has become amenable to interrogate these chromatin states on a genome-wide basis. Recent work in the Ahringer group has shown these chromatin states are organised into large domains, which contain either actively transcribed genes, or genes that are developmentally/environmentally regulated. The project will investigate the regulation, formation and function of these chromatin domains. It will investigate the functional role of the domains with regard to regulation of the genome and cell events. It will also attempt to identify mechanisms and factors involved in the formation and regulation of domains as well as investigating the border regions between domains to elucidate their role in domain definition and function.

基因组功能部分地由作为基因组元件基础的染色质状态控制。由于过去十年的技术发展，在全基因组的基础上询问这些染色质状态变得容易。Ahringer小组最近的工作表明，这些染色质状态被组织成大的结构域，其中包含活跃转录的基因或发育/环境调节的基因。该项目将研究这些染色质结构域的调节、形成和功能。它将调查的功能作用的域方面的基因组和细胞事件的调节。它还将试图确定参与域的形成和调节的机制和因素，以及调查域之间的边界区域，以阐明它们在域定义和功能中的作用。