ENVIRONMENTAL EPIDEMIOLOGY OF ESSENTIAL TREMOR

描述(摘自申请者的摘要)：特发性震颤(ET)是 最常见的震颤障碍，比帕金森氏症流行20倍 疾病。这种疾病在65岁的人群中最为常见。 那里的流行率可能高达23%。在大多数临床系列中， 散发性疾病占ET病例的50%，辩称 对于存在非遗传(环境或职业)原因的ET。 在之前的一项研究中，这是一项基于社区的研究 ET的家族聚集性，我们制定了可靠和有效的方法来研究 ET，包括问卷、临床评定量表和诊断标准。 因为不知道外星人在家庭中聚集的程度，我们 估计ET的家族聚集性。外星人案件的一级亲属 发生ET的可能性仅是对照亲属的3.73倍 提示非遗传因素可能参与了糖尿病的病因。 Et.然而，目前还没有关于环境或职业的研究。 ET的危险因素。因此，尽管它是世界上最大的 普遍存在的神经系统疾病，其中许多病例似乎是 非遗传的，几乎对环境因素一无所知 影响ET的风险。流行病学数据表明，年龄是一种风险。 影响ET的因素。其他可能的病因包括有机氯农药。 (OCPS)，铅，β-咔啉生物碱。锰和有机溶剂。我们 建议对我们以往研究中发现的ET病例进行进一步调查。 采用1：1配对病例对照设计，对300例受试者进行比较 在纽约曼哈顿的哥伦比亚长老会医疗中心照顾他们的ET 300名年龄、性别、种族和电话匹配的正常对照组受试者 交换。我们的主要目标是评估三者之间的联系 环境或职业暴露(OCPS、铅、β-咔啉生物碱) 和ET使用生物测量和/或终身职业史。在……里面 此外，我们将评估锰、有机溶剂之间的关联 和ET使用终身职业史。

DESCRIPTION (Adapted from applicant's abstract): Essential tremor (ET) is the most common tremor disorder, twenty times more prevalent than Parkinson's disease. The disease is most prevalent among individuals > 65 years of age where prevalence may be as high as 23 percent. In most clinical series, sporadic forms of the disease account for > 50 percent of the ET cases, arguing for the presence of non-genetic (environmental or occupational) causes of ET. During a previous study, which was a community-based study of the familial aggregation of ET, we developed reliable and valid methods to study ET, including questionnaires, clinical rating scales, and diagnostic criteria. Because it was not known to what extent ET clustered within families, we estimated the familial aggregation of ET. A first-degree relative of an ET case was only 3.73 times more likely to develop ET than a relative of a control subject, suggesting that non-genetic factors may contribute to the etiology of ET. However, at present, there are no studies of environmental or occupational risk factors for ET. Therefore, despite the fact that it is one of the most prevalent neurological disorders, and many of the cases appear to be non-genetic, almost nothing is known about the environmental factors which influence the risk for ET. Epidemiological data suggest that age is a risk factor for ET. Other etiologic possibilities include organochlorine pesticides (OCPs), lead, beta-carboline alkaloids. manganese, and organic solvents. We propose to further investigate the ET cases identified in our previous studies. Using a 1:1 matched case-control design, we will compare 300 ET cases receiving care for their ET at Columbia-Presbyterian Medical Center, Manhattan N.Y. to 300 normal control subjects matched by age, gender, ethnicity, and telephone exchange. Our primary aim is to evaluate the associations between three environmental or occupational exposures (OCPS, lead, beta-carboline alkaloids) and ET using biological measures and/or a lifetime Occupational History. In addition, we will evaluate the associations between manganese, organic solvents and ET using a lifetime Occupational History.