ENVIRONMENTAL EPIDEMIOLOGY OF ESSENTIAL TREMOR

特发性震颤的环境流行病学

• 批准号: 6540197
• 负责人: ELAN D LOUIS
• 金额: $ 63.64万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6540197
• 关键词: alkaloids; chlorohydrocarbon insecticide; clinical research; disease /disorder proneness /risk; environmental exposure; environmental toxicology; human subject; lead; manganese; nervous system disorder epidemiology; occupational hazard; pyridoindole; tremor

DESCRIPTION (Adapted from applicant's abstract): Essential tremor (ET) is the most common tremor disorder, twenty times more prevalent than Parkinson's disease. The disease is most prevalent among individuals > 65 years of age where prevalence may be as high as 23 percent. In most clinical series, sporadic forms of the disease account for > 50 percent of the ET cases, arguing for the presence of non-genetic (environmental or occupational) causes of ET. During a previous study, which was a community-based study of the familial aggregation of ET, we developed reliable and valid methods to study ET, including questionnaires, clinical rating scales, and diagnostic criteria. Because it was not known to what extent ET clustered within families, we estimated the familial aggregation of ET. A first-degree relative of an ET case was only 3.73 times more likely to develop ET than a relative of a control subject, suggesting that non-genetic factors may contribute to the etiology of ET. However, at present, there are no studies of environmental or occupational risk factors for ET. Therefore, despite the fact that it is one of the most prevalent neurological disorders, and many of the cases appear to be non-genetic, almost nothing is known about the environmental factors which influence the risk for ET. Epidemiological data suggest that age is a risk factor for ET. Other etiologic possibilities include organochlorine pesticides (OCPs), lead, beta-carboline alkaloids. manganese, and organic solvents. We propose to further investigate the ET cases identified in our previous studies. Using a 1:1 matched case-control design, we will compare 300 ET cases receiving care for their ET at Columbia-Presbyterian Medical Center, Manhattan N.Y. to 300 normal control subjects matched by age, gender, ethnicity, and telephone exchange. Our primary aim is to evaluate the associations between three environmental or occupational exposures (OCPS, lead, beta-carboline alkaloids) and ET using biological measures and/or a lifetime Occupational History. In addition, we will evaluate the associations between manganese, organic solvents and ET using a lifetime Occupational History.

描述（改编自申请人的摘要）：特发性震颤（ET）是一种 最常见的震颤障碍，比帕金森病的发病率高20倍 疾病该疾病在65岁以上的人群中最为流行 患病率可能高达23%。在大多数临床系列中， 这种疾病的散发形式占ET病例的50%以上， 非遗传（环境或职业）原因的ET的存在。 在以前的一项研究中，这是一项以社区为基础的研究， ET的家族聚集性，我们开发了可靠和有效的方法来研究 ET，包括问卷调查、临床评定量表和诊断标准。 因为不知道ET在家庭中聚集的程度，我们 估计ET的家族聚集性。一个外星人的一级亲属 患ET的可能性仅为对照组亲属的3.73倍 受试者，这表明非遗传因素可能有助于病因学 ET.然而，目前还没有环境或职业方面的研究。 ET的危险因素因此，尽管它是世界上 流行的神经系统疾病，许多病例似乎是 非遗传的，几乎没有什么是已知的环境因素， 影响ET的风险。流行病学数据表明，年龄是一个风险， 的因素。其他病因可能包括有机氯农药 （有机氯农药），铅，β-咔啉生物碱。锰和有机溶剂。我们 建议进一步调查我们以前研究中发现的ET病例。 采用1：1配比的病例对照设计，我们将比较300例接受 在纽约曼哈顿的哥伦比亚长老会医疗中心照顾他们的ET。到 300名按年龄、性别、种族和电话匹配的正常对照受试者 交易所我们的主要目的是评估三个之间的关联 环境或职业暴露（OCPS、铅、β-咔啉生物碱） 和ET使用生物措施和/或终身职业史。在 此外，我们将评估锰，有机溶剂， 和ET使用终身职业史。