How does DNA damage alter nuclear mRNA export in humans?

DNA 损伤如何改变人类核 mRNA 输出？

• 批准号: 1943740
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1943740
• 关键词: How; does; DNA; damage; alter

Human cells regulate which mRNAs are exported from the nucleus to the cytoplasm in response to DNA damage. In this project you will use computational and molecular biology approaches to provide a genome wide view of how mRNA export changes in response to DNA damage. The project will utilise a range of cutting edge techniques including high throughput DNA sequencing, CRISPR and RNA interference to dissect the biological process. Training in both computational and molecular biology techniques will be provided ensuring the student is fully prepared for 21st century quantitative biology.

人类细胞调节哪些mRNAs从细胞核输出到细胞质，以响应DNA损伤。在这个项目中，你将使用计算和分子生物学的方法来提供一个基因组范围的观点，即mRNA输出如何改变以响应DNA损伤。该项目将利用一系列尖端技术，包括高通量DNA测序、CRISPR和RNA干扰来剖析生物过程。将提供计算和分子生物学技术方面的培训，确保学生为21世纪的数量生物学做好充分准备。