This project will hunt for aquatic bladder carcinogens by chlorinating authentic and simulated drinking water samples under controlled laboratory cond

该项目将通过在受控实验室条件下对真实和模拟饮用水样品进行氯化来寻找水生鳔致癌物

• 批准号: 1944033
• 金额: --
• 依托单位: University of Surrey
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1944033
• 关键词: project; will; hunt; aquatic; bladder

Epidemiological studies have shown long-term consumption of chlorinated drinking water is associated with an enhanced risk of developing bladder cancer. The cause of this link remains obscure, although it is assumed that disinfection byproducts are implicated. These are generated during drinking water treatment from reactions between precursor compounds (both organic and inorganic) and disinfectants (chlorine being the commonest). Many hundreds of disinfection byproducts are known to occur in drinking water, which reflects both precursor diversity and the complexity of the chemistry involved. However, there are no definite bladder carcinogens amongst their number. Thus, there is a mismatch between the evidence from analytical chemistry, toxicology and epidemiology. A plausible explanation is that bladder carcinogens in drinking water are being missed or overlooked. This project will hunt for aquatic bladder carcinogens by chlorinating authentic and simulated drinking water samples under controlled laboratory conditions. The products from these reactions will be analysed by a range of analytical techniques, focussing on molecules with the chemical functionality found in known bladder carcinogens

流行病学研究表明，长期饮用氯化饮用水会增加患膀胱癌的风险。这种联系的原因仍然不清楚，尽管假设与消毒副产物有关。这些是在饮用水处理过程中由前体化合物（有机和无机）与消毒剂（最常见的氯）之间的反应产生的。已知饮用水中存在数百种消毒副产物，这反映了前体的多样性和所涉及化学的复杂性。然而，其中并没有明确的膀胱致癌物。因此，分析化学、毒理学和流行病学的证据之间存在不匹配。一个似乎合理的解释是，饮用水中的膀胱致癌物被忽视或忽视了。该项目将通过在受控实验室条件下对真实和模拟饮用水样品进行氯化来寻找水生鳔致癌物。这些反应的产物将通过一系列分析技术进行分析，重点关注具有已知膀胱致癌物中化学功能的分子