IN VITRO FIBRIL FORMATION BY MUTANT ALPHA SYNUCLEIN: PARKINSON DISEASE
IN VITRO FIBRIL FORMATION BY MUTANT ALPHA SYNUCLEIN: PARKINSON DISEASE
批准号:
6478956
负责人:
PETER T LANSBURY
金额:
$5.36万
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-07-01 至 2002-06-30
中文摘要
通过吸毒将滥用药物传播给婴儿
在一个获得胎粪的州项目中对怀孕进行监测
从医院选出的代表不同阶层的新生儿
在整个人口中。出乎意料的高阳性率
四氢大麻素类化合物的结果需要进一步分析
保留的先前检查的胎粪样本的剩余部分
以确定标准方法(FPIA)是否给出假阳性。
一种质谱学方法被设计出来,类似于发表的
方法,但进行了修改以处理存储的样本。质谱学
方法显示总有效率较低。所取得的成果已经
由专门研究这种类型的商业实验室验证
化验和最近收集的进一步样本已提交用于
分析。
英文摘要
Transmission of abused drugs to infants through drug use during
pregnancy is being monitored in a state program that obtains meconium
from newborns in hospitals selected to represent the various strata
among the whole population. Unexpectedly high rates of positive
results for tetrahydrocannabinoids has necessitated further analysis
of the reserved remainder of thepreviously examined meconium samples
to determine whether the standard method (FPIA) gives false positives.
A mass spectrometric method was devised, similar to a published
method, butmodified to handle stored samples. The mass spectrometric
method indicated a lower overall rate. Results obtained have been
verified by a commercial laboratory that specializes in this type of
assay and further recently collected samples have been submitted for
analysis.
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会议论文
Facility for drug testing in alpha-syn transgenic drosophila & new models of PD
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批准号:7009789
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项目类别:
-
资助金额:$8.57万
-
财政年份:2005
-
负责人:PETER T LANSBURY
-
依托单位:
Discovery of highly toxic synuclein sequence variants
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批准号:7013561
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项目类别:
-
资助金额:$8.54万
-
财政年份:2005
-
负责人:PETER T LANSBURY
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依托单位:
A High-Throughput Assay-SOD1 Aggregation Inhibitors(RMI)
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批准号:7022025
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项目类别:
-
资助金额:$21.88万
-
财政年份:2005
-
负责人:PETER T LANSBURY
-
依托单位:
Discovery of highly toxic synuclein sequence variants
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批准号:6900738
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项目类别:
-
资助金额:$8.73万
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财政年份:2005
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负责人:PETER T LANSBURY
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依托单位:
Biochemistry of PD gene products
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批准号:7009781
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项目类别:
-
资助金额:$38.26万
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财政年份:2005
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负责人:PETER T LANSBURY
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依托单位:
Administrative Core
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批准号:7009793
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项目类别:
-
资助金额:$3.67万
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财政年份:2005
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负责人:PETER T LANSBURY
-
依托单位:
High Throughout Assay to Probe UCH-L1 Ligase Inhibitors
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批准号:6834684
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项目类别:
-
资助金额:$20.0万
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财政年份:2004
-
负责人:PETER T LANSBURY
-
依托单位:
High Throughout Assay to Probe UCH-L1 Ligase Inhibitors
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批准号:6912804
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项目类别:
-
资助金额:$20.0万
-
财政年份:2004
-
负责人:PETER T LANSBURY
-
依托单位:
MASS SPECTROMETRY OF UCH-L1
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批准号:6978522
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项目类别:
-
资助金额:$0.07万
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财政年份:2004
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负责人:PETER T LANSBURY
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依托单位:
ATOMIC FORCE MICROSCOPY FOR ANALYSIS OF AMYLOIDOGENESIS
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批准号:6469198
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项目类别:
-
资助金额:$21.7万
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财政年份:2001
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负责人:PETER T LANSBURY
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依托单位:
Structural biology/ biochemistry--alpha synuclein & other PD linked gene products
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批准号:6499886
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项目类别:
-
资助金额:$24.81万
-
财政年份:2001
-
负责人:PETER T LANSBURY
-
依托单位:
IN VITRO FIBRIL FORMATION BY MUTANT ALPHA SYNUCLEIN: PARKINSON DISEASE
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批准号:6345232
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项目类别:
-
资助金额:$0.93万
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财政年份:2000
-
负责人:PETER T LANSBURY
-
依托单位:
Familial Parkinson's Disease: Clues to Pathogenesis
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批准号:7285218
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项目类别:
-
资助金额:$150.46万
-
财政年份:2000
-
负责人:PETER T LANSBURY
-
依托单位:
Familial Parkinson's Disease: Clues to Pathogenesis
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批准号:7495107
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项目类别:
-
资助金额:$150.57万
-
财政年份:2000
-
负责人:PETER T LANSBURY
-
依托单位:
ATOMIC FORCE MICROSCOPY FOR ANALYSIS OF AMYLOIDOGENESIS
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批准号:6325705
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项目类别:
-
资助金额:$23.47万
-
财政年份:2000
-
负责人:PETER T LANSBURY
-
依托单位:
ATOMIC FORCE MICROSCOPY FOR ANALYSIS OF AMYLOIDOGENESIS
-
批准号:6345895
-
项目类别:
-
资助金额:$21.7万
-
财政年份:2000
-
负责人:PETER T LANSBURY
-
依托单位:
Familial Parkinson's Disease: Clues to Pathogenesis
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批准号:6968328
-
项目类别:
-
资助金额:$145.78万
-
财政年份:2000
-
负责人:PETER T LANSBURY
-
依托单位:
Structural biology/ biochemistry--alpha synuclein & other PD linked gene products
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批准号:6354785
-
项目类别:
-
资助金额:$24.81万
-
财政年份:2000
-
负责人:PETER T LANSBURY
-
依托单位:
Familial Parkinson's Disease: Clues to Pathogenesis
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批准号:7122034
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项目类别:
-
资助金额:$150.33万
-
财政年份:2000
-
负责人:PETER T LANSBURY
-
依托单位:
Familial Parkinson's Disease: Clues to Pathogenesis
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批准号:7675949
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项目类别:
-
资助金额:$155.19万
-
财政年份:2000
-
负责人:PETER T LANSBURY
-
依托单位:
海外基金