Role Of Hiv Disease In The Pathogenesis Of Hepatitis B

艾滋病毒疾病在乙型肝炎发病机制中的作用

• 批准号: 6507015
• 负责人: Anthony S. Fauci
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6507015
• 关键词: AIDS therapy; HIV infections; adefovir; comorbidity; drug resistance; hepatitis B; hepatitis B virus group; human immunodeficiency virus; human subject; human therapy evaluation; lamivudine; liver cirrhosis; pathologic process; patient oriented research; tissue /cell culture; virus load

HIV related opportunistic infections have declined significantly as a result of anti-retroviral therapy. However, other serious medical diseases, such as advanced liver disease, have become an important area of concern in the clinical care of HIV-infected individuals. In this regard, HIV infection is thought to have a negative impact on the progression of liver disease as a result of chronic hepatitis B virus (HBV) infection. Unfortunately, many individuals with HBV disease fail first-line therapy with lamivudine. Adefovir dipivoxil may offer a therapeutic option to HIV- infected individuals who are co-infected with HBV who have failed lamivudine therapy. LIR investigators have recently opened two clinical trials assessing the safety and efficacy of low-dose adefovir (10 mg daily) for the treatment of chronic hepatitis B in HIV-infected individuals who have HBV-related liver disease and persistent HBV plasma viremia despite lamivudine therapy. In addition to evaluating the clinical safety and efficacy of adefovir, we are investigating the impact of HIV infection on HBV-specific cellular immune function. These studies will expand our understanding of the pathogenesis and treatment of HBV disease in HIV-infected people.

由于抗逆转录病毒疗法，与艾滋病毒有关的机会性感染大幅减少。然而，其他严重的医学疾病，如晚期肝病，已成为艾滋病毒感染者临床护理的一个重要领域。在这方面，HIV感染被认为对慢性B型肝炎病毒（HBV）感染导致的肝病进展具有负面影响。不幸的是，许多HBV感染者不能用拉米夫定进行一线治疗。阿德福韦酯可能为拉米夫定治疗失败的合并HBV感染的HIV感染者提供一种治疗选择。LIR研究人员最近开展了两项临床试验，评估低剂量阿德福韦酯（每日10 mg）治疗慢性B型肝炎的安全性和有效性，这些患者在接受拉米夫定治疗后仍有HBV相关肝病和持续HBV血浆病毒血症。除了评价阿德福韦酯的临床安全性和有效性外，我们还在研究HIV感染对HBV特异性细胞免疫功能的影响。这些研究将扩大我们对HIV感染者HBV疾病的发病机制和治疗的理解。