Elucidating the pathological role and predictive value of mental health disorder risk genes

阐明精神健康障碍风险基因的病理作用和预测价值

• 批准号: nhmrc : 1196841
• 金额: $ 156.23万
• 依托单位国家: 澳大利亚
• 项目类别: Investigator Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://researchdata.edu.au/elucidating-pathological-role-risk-genes/1779195
• 关键词: Elucidating; pathological; role; predictive; value

Mental health disorders such as schizophrenia and depression are common and often debilitating conditions. The genes in our DNA play a large role in who develops these disorders and many risk genes have been identified. We will investigate when and how these risk genes are “switched on” to work out how they cause disease and to accurately predict who is at high risk of developing a mental health disorder. These advances will help us to understand disease causation and to improve treatments.

精神健康障碍，如精神分裂症和抑郁症是常见的，往往使人衰弱的条件。我们DNA中的基因在谁患上这些疾病中起着很大的作用，许多风险基因已经被确定。我们将研究这些风险基因何时以及如何“开启”，以找出它们如何导致疾病，并准确预测谁是发展心理健康障碍的高风险人群。这些进展将帮助我们了解疾病的原因并改进治疗方法。