TRAINGING PROGRAM IN CANCER BIOLOGY

描述(申请者描述)：肿瘤生物学培训计划 是一个为博士后和博士后实习生设计的项目，旨在产生 将专门关注生物和化学问题的调查人员 在他们的研究生涯中与癌症问题有关。我们的节目将 向学员传授清晰的知识，使他们了解 人类癌症的基本问题和临床问题。该计划已扎根于 维克森林大学癌症中心肿瘤生物学系； 所有教职员工要么是癌症生物学系的初级成员，要么是 癌症生物学专业交叉任命。交叉任命的成员来自 化学、生物化学、病理学、放射肿瘤学和 血液学/肿瘤学。受训人员将包括博士前博士生， 博士后S和医学博士S希望补充他们的临床培训 接受过癌症研究方面的培训。所有博士前实习生都将成为候选人 申请癌症生物学博士学位，维克大学的学位候选人计划 森林大学于1997年秋季学期开学。博士后和博士后 实习生将结合研究、研讨会/专题讨论会参与，以及 由系教员讲授的讲授课程内容包括DNA损伤和 修复，癌细胞生物学，信号转导，细胞周期控制，肿瘤 免疫学、基因治疗以及临床和流行病学问题概述 在人类癌症中。研究将由系教员指导； 具体任务将由计划执行委员会在#年进行。 与监督委员会协商。培训计划的主要特点 包括广泛指导和评估过程以及一支拥有 结合临床和基础科学的积极研究项目。这次培训 该计划将通过三种方式实现国家癌症研究所的目标： (1)它将产生有能力关注癌症问题的调查人员 他们的研究生涯；(2)它将提供跨越化学- 生物接口；(3)将强调基础科学与科学之间的联系 以及人类癌症的临床问题。

DESCRIPTION (Applicant's Description): The Training Program in Cancer Biology is a program for pre- and postdoctoral trainees designed to produce investigators who will focus on biological and chemical issues specifically related to the cancer problem during their research careers. Our program will impart to trainees a clear understanding of the relationships between the basic problems and clinical issue of human cancer. The Program is anchored in the Department of Cancer Biology of the Wake Forest University Cancer Center; all faculty are either primary Cancer Biology Department members, or are cross-appointed to Cancer Biology. The cross appointees come from the Departments of Chemistry, Biochemistry, Pathology, Radiation oncology, and Hematology/Oncology. Trainees will include predoctoral Ph.D. candidates, postdoctoral Ph.D.'s and M.D.'s desiring to supplement their clinical training with training in cancer research. All predoctoral trainees will be candidates for a Ph.D. degree in Cancer Biology, a degree candidacy program of Wake Forest University begun in the fall semester, 1997. Pre- and postdoctoral traineeships will combine research, seminar/symposia participation, plus didactic coursework taught by Department faculty covering DNA damage and repair, cancer cell biology, signal transduction, cell cycle control, tumor immunology, gene therapy and an overview of clinical and epidemiologic issues in human cancer. Research will supervised by Departmental faculty preceptors; specific assignments will be made by the Program executive committee in consultation with an oversight board. Key features of the Training Program include an extensive mentoring and evaluation process and a faculty with active research programs that mesh clinical and basic science. This training program will address the goals of the National Cancer Institute in three ways: (1) it will produce investigators equipped to focus on the cancer problem in their research careers; (2) it will provide education spanning the chemical- biological interface; (3) it will emphasize the linkage between basic science and the clinical problems of human cancer.