Antigen discovery and antibody engineering against avian paramyxovirus

针对禽副粘病毒的抗原发现和抗体工程

• 批准号: 1947933
• 金额: --
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1947933
• 关键词: Antigen; discovery; antibody; engineering; against

Newcastle Disease Virus is a highly infectious Avulavirus with up to a 100% fatality rate in the birds it infects. It constitutes a major threat to the poultry industry, especially in the developing world, as well as to small scale farmers. Current vaccines are only fully effective against some strains of the virus and confer little protection against newer, more virulent strains. The aims of this project are to attempt to develop a vaccine against these newly emerging strains of virus through the expression of modified Newcastle disease virus fusion proteins, in cell culture. These will then be used to generate broadly neutralising antibodies against multiple strains in-vivo. These will be used to further study the F protein structure with a view to creating an effective recombinant vaccine, for poultry, against the virus. AfS, ENWW

纽卡斯尔病病毒是一种高度传染性的禽流感病毒，在其感染的禽类中具有高达100%的死亡率。它对家禽业构成了重大威胁，特别是在发展中国家，以及对小规模农民。目前的疫苗只能对某些病毒株完全有效，对更新的、毒性更强的病毒株几乎没有保护作用。本项目的目的是试图通过在细胞培养物中表达修饰的纽卡斯尔病病毒融合蛋白来开发针对这些新出现的病毒株的疫苗。然后，这些将用于在体内产生针对多种菌株的广泛中和抗体。这些将用于进一步研究F蛋白的结构，以期为家禽创造一种有效的重组疫苗。AfS，ENWW