MECHANISMS & PERFORMANCE OF TRACEABLE UHMWPE IMPLANTS

机制

• 批准号: 6533026
• 负责人: STEVEN MICHAEL KURTZ
• 金额: $ 31.02万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-07 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6533026
• 关键词: X ray; age difference; arthroplasty; biomaterial evaluation; biomaterial interface interaction; body physical activity; body weight; calorimetry; clinical research; data collection methodology /evaluation; gamma radiation; gender difference; hip prosthesis; information systems; infrared spectrometry; longitudinal human study; mechanical stress; medical implant science; metal complex; polyethylenes; statistics /biometry

DESCRIPTION (provided by applicant): Degradation of ultra high molecular weight polyethylene (hereafter, polyethylene) joint replacement components after gamma irradiation in air continues to be recognized as a significant clinical problem limiting the longevity of total joint arthroplasties, which represent the standard of care for patients with advanced degenerative joint disease. Oxidative degradation of polyethylene has been associated with accelerated wear, brittle fracture, and delamination of total joint replacement components. Although it is now recognized that the degradation of polyethylene plays an important role in the damage mechanisms of orthopaedic components, it is still unclear the extent to which the mechanical degradation of polyethylene relates to the overall clinical performance of total hip arthroplasty, due in part to the logistical difficulty in tracing the sterilization and shelf aging history of the components, and also due to the experimental difficulty in directly measuring the mechanical behavior of retrieved implants. The range of mechanical behavior associated with traceable, clinically retrieved orthopedic components is critically needed to guide the development of improved polyethylenes, such as the highly crosslinked polyethylenes which have recently been introduced into clinical practice for total hip arthroplasty. The purpose of this proposed research is to examine the influence of mechanical degradation after implantation on the clinical performance of metal-backed acetabular components for total hip arthroplasty.

性状（由申请方提供）：超高分子量降解 聚乙烯（以下简称聚乙烯）关节置换组件， 空气中的辐射仍然被认为是重要的临床问题 限制了全关节置换术的寿命， 晚期退行性关节疾病患者的标准治疗。 聚乙烯的氧化降解与加速降解有关。 磨损、脆性断裂和全关节置换部件的分层。 尽管现在认识到聚乙烯的降解在 在骨科部件的损伤机制中起着重要作用，它仍然是 不清楚聚乙烯机械降解的程度 全髋关节置换术的整体临床性能，部分原因是 追踪灭菌和货架老化历史的后勤困难 的成分，也由于直接进行实验的困难 测量取出的植入物的机械性能。的范围 与可追溯的临床检索骨科相关的机械行为 关键是需要有一个组件来指导改进的 聚乙烯，例如最近已经 已被引入全髋关节置换术的临床实践。目的 这项研究的目的是研究机械降解的影响， 植入后对金属背衬髋臼临床性能的影响 用于全髋关节置换术的组件。