Developing PROTACs from chemical probes - applications in cancer research

从化学探针开发 PROTAC - 在癌症研究中的应用

• 批准号: 1955336
• 金额: --
• 依托单位: University of Sussex
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1955336
• 关键词: Developing; PROTACs; chemical; probes; applications

This project aims to initiate PROTACs research designed to deliver modified chemical probes that can be used to interrogate the function of some of the most intractable targets in cancer biology. It will explore two main ideas: targeting the cancer super-controller, Myc using PROTACs, and investigating novel approaches to hybrid molecule and PROTAC generation using different E3 ligases. Bio-Techne provides both commercial and chemical expertise that will allow the novel PROTAC tools to be quickly disseminated throughout the research community.

该项目旨在启动PROTAC研究，旨在提供经修饰的化学探针，可用于询问癌症生物学中一些最棘手的靶标的功能。它将探索两个主要想法：使用PROTAC靶向癌症超级控制器Myc，并研究使用不同E3连接酶产生杂交分子和PROTAC的新方法。Bio-Techne提供商业和化学专业知识，使新的PROTAC工具能够在整个研究界迅速传播。