Developing PROTACs from chemical probes - applications in cancer research

该项目旨在启动PROTACs研究，旨在提供改良的化学探针，可用于询问癌症生物学中一些最棘手的目标的功能。它将探索两个主要思路：利用PROTACs靶向癌症超级控制器Myc，并研究使用不同E3连接酶生成杂交分子和PROTAC的新方法。Bio-Techne提供商业和化学专业知识，这将使新的PROTAC工具能够在整个研究界迅速传播。

This project aims to initiate PROTACs research designed to deliver modified chemical probes that can be used to interrogate the function of some of the most intractable targets in cancer biology. It will explore two main ideas: targeting the cancer super-controller, Myc using PROTACs, and investigating novel approaches to hybrid molecule and PROTAC generation using different E3 ligases. Bio-Techne provides both commercial and chemical expertise that will allow the novel PROTAC tools to be quickly disseminated throughout the research community.