Mechanisms of gastrin-CCKBR/gastrin-annexin II signaling as indicators for non-invasive health monitoring during aging

胃泌素-CCKBR/胃泌素-膜联蛋白 II 信号传导机制作为衰老过程中无创健康监测指标

• 批准号: 1961735
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1961735
• 关键词: Mechanisms; gastrin; CCKBR; annexin; II

In addition to erythrocytes and leucocytes, blood is known to contain cells of endothelial origin from a range of tissues. Many such cells express proteins, such as the peptide hormone gastrin, together with its cognate receptors CCKBR and Annexin II that are involved in tissue homeostasis, and whose activity is associated both with health AND disease. Key to understanding their utility as health biomarkers is a mechanistic understanding of normal and abnormal signaling of such biomarkers. This project aims to use novel filtration technology developed by Asstrimmune, together with expertise in cell signaling and imaging in the Smythe Lab, to develop a highly sensitive biological detection system by which changes in signaling outputs in cell circulating in blood, may be used for the identification of critical change points in aging, indicating a need for further intervention. The project will include a placement at Asstrimmune, Mansfield.

除了红细胞和白细胞之外，已知血液还含有来自一系列组织的内皮来源的细胞。许多这样的细胞表达蛋白质，例如肽激素胃泌素，连同其同源受体CCKBR和膜联蛋白II，其参与组织稳态，并且其活性与健康和疾病两者相关。理解它们作为健康生物标志物的效用的关键是对这些生物标志物的正常和异常信号传导的机械理解。该项目旨在使用Asstrimmune开发的新型过滤技术，以及Smythe实验室在细胞信号传导和成像方面的专业知识，开发一种高灵敏度的生物检测系统，通过该系统，血液中循环细胞中信号输出的变化可用于识别衰老的关键变化点，表明需要进一步干预。该项目将包括在阿斯特里姆恩，曼斯菲尔德安置。