Aerosol Delivery of Influenza Vaccine Candidates and Role of Local Immune Response in Pigs

候选流感疫苗的气雾输送和猪局部免疫反应的作用

• 批准号: 1962255
• 金额: --
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1962255
• 关键词: Aerosol; Delivery; Influenza; Vaccine; Candidates

Influenza A virus is responsible for the major pandemics in the last century. Its ability to infect different hosts, such as human, pigs and birds, and the high mutation rate represents a major challenge in fighting this pathogen. Pigs are natural host of influenza A virus and play a critical role in the emergence of new viruses, being able to be infected with human and avian strains. Current vaccine strategies rely on neutralising antibodies which are strain dependent and therefore need to be updated every year. In this study new broadly protective vaccine candidates will be analysed and different routes of administration compared for their immunogenicity and protection potential. For the first time it will be possible to study the role of lung tissue resident memory T cells in pigs and their function in the context of influenza infection and protection. This project follows the BBSRC "Bioscience for Health" priority area, giving new insights into pigs' health and allowing the study of influenza A virus in a One Health perspective. AfS, ENWW

甲型流感病毒是上个世纪主要流行病的罪魁祸首。它能够感染不同的宿主，如人类、猪和鸟类，并且高突变率是对抗这种病原体的重大挑战。猪是甲型流感病毒的天然宿主，在新病毒的出现中发挥着关键作用，能够感染人类和禽类病毒株。目前的疫苗策略依赖于中和抗体，中和抗体具有毒株依赖性，因此需要每年更新。在这项研究中，将分析新的具有广泛保护性的候选疫苗，并比较不同的给药途径的免疫原性和保护潜力。首次有可能研究猪肺组织驻留记忆 T 细胞的作用及其在流感感染和保护中的功能。该项目遵循 BBSRC“健康生物科学”优先领域，为猪的健康提供了新的见解，并允许从单一健康的角度研究甲型流感病毒。 AfS，ENWW

项目成果

Design of Gadoteridol-Loaded Cationic Liposomal Adjuvant CAF01 for MRI of Lung Deposition of Intrapulmonary Administered Particles.

用于肺内给药颗粒肺沉积 MRI 的负载钆特醇的阳离子脂质体佐剂 CAF01 的设计。

• DOI: 10.1021/acs.molpharmaceut.9b00908
• 发表时间: 2019
• 期刊: Molecular pharmaceutics
• 影响因子: 4.9
• 作者: Thakur A