Aerosol Delivery of Influenza Vaccine Candidates and Role of Local Immune Response in Pigs

甲型流感病毒是上个世纪主要流行病的罪魁祸首。它能够感染不同的宿主，如人，猪和鸟类，以及高突变率是对抗这种病原体的主要挑战。猪是甲型流感病毒的天然宿主，在新病毒的出现中起着关键作用，能够感染人类和禽类毒株。目前的疫苗策略依赖于中和抗体，这是菌株依赖性的，因此需要每年更新。在本研究中，将分析新的广泛保护性候选疫苗，并比较不同给药途径的免疫原性和保护潜力。这将首次有可能研究猪肺组织驻留记忆T细胞的作用及其在流感感染和保护背景下的功能。该项目遵循BBSRC“健康生物科学”优先领域，为猪的健康提供新的见解，并允许从一个健康角度研究甲型流感病毒。AfS，ENWW

Influenza A virus is responsible for the major pandemics in the last century. Its ability to infect different hosts, such as human, pigs and birds, and the high mutation rate represents a major challenge in fighting this pathogen. Pigs are natural host of influenza A virus and play a critical role in the emergence of new viruses, being able to be infected with human and avian strains. Current vaccine strategies rely on neutralising antibodies which are strain dependent and therefore need to be updated every year. In this study new broadly protective vaccine candidates will be analysed and different routes of administration compared for their immunogenicity and protection potential. For the first time it will be possible to study the role of lung tissue resident memory T cells in pigs and their function in the context of influenza infection and protection. This project follows the BBSRC "Bioscience for Health" priority area, giving new insights into pigs' health and allowing the study of influenza A virus in a One Health perspective. AfS, ENWW