COCHLEAR MECHANISMS OF FREQUENCY MICROSTRUCTURE

耳蜗频率微结构机制

• 批准号: 6516177
• 负责人: Lisa J. Stover
• 金额: $ 9.62万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6516177
• 关键词: aging; auditory threshold; behavioral /social science research tag; clinical research; cochlea; cochlear nerve; human subject; mathematical model; model design /development; neural information processing; otoacoustic emission; psychoacoustics; sound frequency

The experiments in this proposal are designed to investigate the frequency microstructure of both auditory thresholds and otoacoustic (OAE) phenomena. The clinical ramifications of frequency microstructure will be explored by examining ears with cochlear impairment. The ultimate goal of this line of research will be to develop more specific diagnostic OAE procedure. The specific questions of the proposal are: 1) Is the cochlear mechanism for frequency microstructure common to both auditory threshold and stimulus frequency OAEs (SFOAEs)? Direct comparison of the microstructure of both threshold and SFOAE from the same normal ears (in terms of frequencies of maxima/minima and amplitude excursion) will be used to evaluate and contrast several opposing hypotheses regarding underlying cochlear mechanisms. 2) Is frequency microstructure in distortion product otoacoustic emissions (DPOAE) frequency functions related to multiple generation sources? Comparison of DPOAE frequency functions as measured with several different primary stimulus protocols among each other and with auditory thresholds will be used to compare between two theories (Allen and Fahey, 1993; Stover, Neely and Gorga;, 1997) 3) Can empirical results be reproduced by, and the hypothesis implemented in a mathematical model of cochlear mechanics? Attempts will be made to incorporate random fluctuations in several aspects of the cochlear partition in a mathematical model of the cochlea (Neely, 1993) which will reproduce empirical data while allowing the model to remain stable. 4) Does loss of frequency microstructure occur in aging in the absence of hearing loss? Frequency microstructure across normal hearing and mild hearing loss ranges will be compared for two age groups of adults carefully matched for audiometric threshold. 5) Can DPOAE frequency microstructure account for the lack of specificity of DPOAEs in clinical diagnostics? Based on earlier experiments a shortened protocol of DPOAE frequency functions will be evaluated on a large population of subjects with normal hearing to mild hearing losses in an attempt to improve clinical estimation of auditory threshold.

本提案中的实验旨在研究 听阈和耳声的频率微观结构 （OAE）现象。 频率微观结构的临床影响 将通过检查有耳蜗损伤的耳朵来进行探索。 这 这一系列研究的最终目标是开发更具体的 诊断性 OAE 程序。 该提案的具体问题是： 1）频率微结构的耳蜗机制是两者共同的吗 听觉阈值和刺激频率 OAE (SFOAE)？ 直接的 阈值和 SFOAE 的微观结构比较 相同的正常耳朵（最大/最小频率和振幅） 游览）将用于评估和对比几个相反的 关于潜在耳蜗机制的假设。 2) 是频率 畸变产物耳声发射 (DPOAE) 中的微观结构 与多个发电源相关的频率函数？ 比较 使用几种不同的初级测量的 DPOAE 频率函数 相互之间以及听觉阈值的刺激协议将 用于比较两种理论（Allen 和 Fahey，1993；Stover， Neely 和 Gorga；，1997) 3) 经验结果能否重现，以及 该假设在人工耳蜗的数学模型中得到实现 机械师？ 将尝试将随机波动纳入 数学模型中耳蜗分区的几个方面 耳蜗（Neely，1993）将重现经验数据，同时允许 模型保持稳定。 4）频率微观结构是否丢失 在没有听力损失的情况下会发生衰老吗？ 频率显微组织 将比较正常听力和轻度听力损失范围 两个年龄组的成年人仔细匹配听力阈值。 5）DPOAE频率微观结构能否解释缺乏 DPOAE 在临床诊断中的特异性？ 基于之前的 实验 DPOAE 频率函数的缩短协议将是 对大量听力正常至轻度的受试者进行评估 听力损失，试图改善听觉的临床评估 临界点。