CORE--MARINE MODELS OF HUMAN DISEASES

描述（由申请人提供）：在本研究的第二个研究核心中， 中心，统一的主题是使用海洋和淡水模型系统 环境健康相关的研究。一般来说，模型的使用 系统作为替代品的病理状态的研究有关的 环境源于直接使用哺乳动物的几个优点 系统这些系统包括：1）雀鲷神经纤维瘤病，2）蟾鱼， 3)鲨鱼免疫学，4）免疫缺失，5）转基因鱼。 人类疾病海洋模型的研究受到高度重视 跨学科的，在这一点上，研究人员在这个研究核心共享 几乎每天都在学习几个领域的知识和方法。第一、 在基本的动物护理、维护和 畜牧技术其次，从实验的角度来看，专业知识是 在生物组织的不同层次上都可以得到， 包括生物化学和分子生物学、病原体生物学、体外细胞 培养和操作（包括电生理学和胚胎学），以及 全动物生理学和血清学方法学。当结合 在海洋和淡水毒素方面的兴趣和专业知识， 人类健康研究核心，调查人员认为，他们是一个强大的 资源的每一个科学家在MFBS，并为 研究人员和NIEHS的使命。

Description (provided by applicant): In the second Research Core of this Center, the unifying theme is the use of marine and freshwater model systems for environmental health-related research. In general, the use of model systems as surrogates for the study of pathological states related to the environment stems from several advantages over the direct use of mammalian system. These systems include: 1) Damselfish Neurofibromatosis, 2) Toadfish, 3) Shark Immunology, 4) Aplysia, 5) Transgenic Fishes. The research in the marine models of human diseases is highly interdisciplinary, in that, investigators in this Research Core share knowledge and approaches in several areas on virtually a daily basis. First, there is a great deal of interactivity in basic animal care, maintenance and husbandry techniques. Second, from an experimental standpoint, expertise is available on a number of different levels of biological organization, including biochemistry and molecular biology, pathogen biology, in vitro cell culture and manipulations (including electrophysiology and embryology), and whole-animal physiological and serological methodology. When combined with the interests and expertise available in the Marine and Freshwater Toxins and Human Health Research Core, the investigators believe they are a powerful resource for each of the individual scientists in the MFBS, and for the investigators and mission of NIEHS.