CORE--MARINE MODELS OF HUMAN DISEASES

描述(由申请人提供)：在本研究的第二个核心中 中心，统一的主题是使用海洋和淡水模型系统 与环境健康相关的研究。一般而言，模型的使用 作为研究与之相关的病理状态的替代系统 环境源于与直接使用哺乳动物相比的几个优势 系统。这些系统包括：1)柔鱼神经纤维瘤病，2)蟾鱼， 3)鲨鱼免疫学，4)海兔，5)转基因鱼类。 在人类疾病的海洋模型方面的研究是高度的。 跨学科，在这项研究的核心中，研究人员分享了 几个领域的知识和方法几乎每天都有。第一, 在基本的动物护理、维护和管理方面有大量的互动 畜牧技术。其次，从实验的角度来看，专业知识是 在许多不同级别的生物组织中可用， 包括生物化学和分子生物学、病原生物学、体外细胞 培养和操作(包括电生理学和胚胎学)，以及 全动物生理学和血清学方法学。当与 对海洋和淡水毒素以及 人类健康研究核心，研究人员认为他们是一个强大的 MFBS中每个科学家的个人资源，以及 NIEHS的研究人员和使命。

Description (provided by applicant): In the second Research Core of this Center, the unifying theme is the use of marine and freshwater model systems for environmental health-related research. In general, the use of model systems as surrogates for the study of pathological states related to the environment stems from several advantages over the direct use of mammalian system. These systems include: 1) Damselfish Neurofibromatosis, 2) Toadfish, 3) Shark Immunology, 4) Aplysia, 5) Transgenic Fishes. The research in the marine models of human diseases is highly interdisciplinary, in that, investigators in this Research Core share knowledge and approaches in several areas on virtually a daily basis. First, there is a great deal of interactivity in basic animal care, maintenance and husbandry techniques. Second, from an experimental standpoint, expertise is available on a number of different levels of biological organization, including biochemistry and molecular biology, pathogen biology, in vitro cell culture and manipulations (including electrophysiology and embryology), and whole-animal physiological and serological methodology. When combined with the interests and expertise available in the Marine and Freshwater Toxins and Human Health Research Core, the investigators believe they are a powerful resource for each of the individual scientists in the MFBS, and for the investigators and mission of NIEHS.