CORE--NEUROTOXICOLOGY

研究人员在研究核心4中进行的研究寻求 为了描述遗传、衰老和环境之间的相互作用 神经退行性疾病的发病机制，以及阐明 某些神经毒物的作用机制。研究核心的目标 将继续促进实验室调查人员之间的整合 和同事一起参与人体研究，培育一种新的发展 神经退行性疾病的环境和遗传风险因素项目 疾病，并开发一个啮齿动物行为实验室，供中心使用 调查人员。神经毒理学研究核心由八个部分组成 来自环境卫生、神经内科的调查人员 外科、病理学、医学遗传学和流行病学，五个分支机构 来自环境卫生、神经内科和 华盛顿大学的生物工程和来自外部的研究人员 研究机构。除了广泛参与重大问题之外 神经毒理学，科斯塔博士与弗隆博士合作探索基因 对氧磷酶基因多态性与有机磷的易感性 杀虫剂以及与Checkoway博士一起研究单胺氧化酶B的多态性 D2受体与帕金森病、S病的关系伯巴赫博士 继续研究铅对非人类灵长类动物的发育毒性 并承担了开发啮齿动物行为实验室的任务， 在吉尔伯特博士离开医院后，科斯塔博士和弗隆博士 上大学。马丁博士加入研究核心提供了 阿尔茨海默病的额外力量？S病。调查人员已经开发出 进行了广泛的协作，并在其 合作研究。未来的计划包括刺激增加 核心调查人员之间的互动，实施啮齿动物行为 实验室，在神经毒理学中培养生态遗传学的概念 社区，促进核心调查人员的研究，制定 神经退行性疾病的遗传和环境风险项目 疾病，并催化更多的合作和刺激新的系列 研究的成果。

The research conducted by investigators in Research Core 4 seeks to characterize the interplay between genetics, aging, and the environment in the pathogenesis of neurodegenerative diseases, as well as to elucidate the mechanism of action of certain neurotoxicants. The goals of the Research Core are to continue to facilitate the integration between laboratory investigators and colleagues involved in human studies, to foster the development of a new program project on environmental and genetic risk factors in neurodegenerative diseases, and to develop a rodent behavioral laboratory for use by Center investigators. The Neurotoxicology Research Core consists of eight Investigators, from the Departments of Environmental Health, Neurological Surgery, Pathology, Medical Genetics, and Epidemiology, five Affiliate Investigators from the Departments of Environmental Health, Neurology, and Bioengineering at the University of Washington, and investigators from outside research institutions. In addition to broad involvement in major issues in neurotoxicology, Dr. Costa collaborates with Dr. Furlong exploring genetic polymorphisms in paraoxonase and susceptibility to organophosphorus insecticides and with Dr. Checkoway on polymorphisms of monoamine oxidase B and D2 receptors as risk factors in Parkinson?s disease. Dr. Burbacher continues his studies of developmental toxicity of lead in non-human primates and has taken on the task of developing a rodent behavioral laboratory, with Drs. Costa and Furlong, following the departure of Dr. Gilbert from the university. The addition of Dr. Martin to the research core has provided additional strength in Alzheimer?s disease. The investigators have developed extensive collaborations and have utilized the facility cores in their collaborative research. Future plans include the stimulation of increased interactions between Core investigators, implementation of a rodent behavioral laboratory, fostering the concept of ecogenetics in the neurotoxicology community, facilitating research by the Core investigators, developing a program project in genetic and environmental risks in neurodegenerative diseases, and catalyzing additional collaborations and stimulating new lines of research.