CHANGES IN HEALTH: SOCIO-ECONOMIC STATUS AND PATHWAYS

描述(改编自调查人员摘要)：白厅II研究 10,308名男性和女性公务员，入职年龄为35-55岁(1985-1988年)， 是为了研究特定的心理社会、生活方式、 生化和生理因素可能对此作出解释 不平等。这些暴露中与年龄相关的真实变化，或累积 纵向测量的暴露被假设为预测SES的变化 健康状况随着年龄的变化而变化。在队列的10年跟踪中，NIA 支持收集数据，以重复健康结果衡量标准 功能、认知功能、代谢综合征的组成部分和 APOE基因分型。这个应用程序申请资金来分析数据 到目前为止收集的资金，并对15年期的具体内容作出贡献 队列的后续行动。这笔资金将使调查人员能够 积累更多终端并跟踪老年人的健康功能，联系 他们早年和中年的暴露，从而使我们能够建立 疾病的心理、社会和生物途径以及健康不平等。 应用程序的目的是：(1)描述和解释变化的模式 与SES相关的健康状况的年龄；(2)确定梯度是否 从退休前到退休，在健康方面的功能不同；(3)检查 自尊与认知功能随年龄变化的关系 通过检查原因来研究连接SES的特定生物路径 以及它们随年龄变化的后果。白厅二号的研究是独一无二的 准备回答这些问题，提供：公务员职系作为 卓越的SES测量；与参与者相比的纵向设计 年轻的在进入时允许检测变化的前置因素的；重复的 暴露的测量；广泛的暴露数据；相当大的能力 检测与年龄相关的变化及其与SES的相互作用；广泛的健康状况 结果包括健康和认知功能， 代谢综合征、死亡率、非致命性诊断和疾病缺勤。

DESCRIPTION (adapted from investigator's abstract): The Whitehall II study of 10,308 male and female civil servants aged 35-55 years at entry (1985-1988), was established to examine the role of specific psychosocial, lifestyle, biochemical and physiological factors as possible explanations of these inequalities. True age related changes in these exposures, or cumulative exposure measured longitudinally, are hypothesized to predict changes in SES differences in health with age. At the 10-year follow up of the cohort, NIA support funded collection of data to repeat outcome measures of health functioning, cognitive functioning, components of the metabolic syndrome and ApoE genotyping. This application requests funding to analyze the data collected to date and to contribute to specific elements of the 15-year follow-up of the cohort. This funding will enable the investigators to accumulate more endpoints and track health functioning into older age, relate them to early life and mid-life exposures, and thereby allow us to establish psychosocial and biological pathways of disease and health inequalities. The aims of the application are: (1) To describe and explain patterns of change with age in health status in relation to SES; (2) To determine if the gradient in health functioning differs from pre-retirement to retirement; (3) To examine the relationship between SES and change in cognitive function with age; (4) To investigate specific biological pathways linking SES by examining the causes and consequences of their change with age. The Whitehall II study is uniquely poised to address these questions, offering: civil service grade as an excellent measure of SES; longitudinal design with participants comparatively young at entry allowing the detection of antecedents of change; repeated measures of exposures; a wide range of exposure data; substantial power to detect age-related change, and its interaction with SES; wide range of health outcomes including health and cognitive functioning, components of the metabolic syndrome, mortality, non-fatal diagnoses and sickness absence.