Identifying cyclic peptide inhibitors of the Myc/Max protein-protein interaction

鉴定 Myc/Max 蛋白质-蛋白质相互作用的环肽抑制剂

• 批准号: 1990345
• 金额: --
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1990345
• 关键词: Identifying; cyclic; peptide; inhibitors; Myc

We are going to use a newly developed, microfluidic-based platform to generate and screen libraries of over a hundred million cyclic peptides against the Myc/Max protein-protein interaction. This protein-protein interaction has been heavily implicated in the cancer, however, there are currently no therapeutics that target myc/max. we will use this challenging target to assess the limits of our screening platform. Once a cyclic peptide that inhibits this protein-protein interaction has been identified, we will use a medicinal chemistry approach to improve its potency.

我们将使用一种新开发的基于微流体的平台来生成和筛选超过1亿个环肽库，以对抗Myc/Max蛋白质-蛋白质相互作用。这种蛋白质-蛋白质相互作用与癌症密切相关，然而，目前还没有靶向myc/max的治疗方法。我们会利用这个具挑战性的目标，评估我们的筛选平台的局限性。一旦发现了抑制这种蛋白质-蛋白质相互作用的环肽，我们将使用药物化学方法来提高其效力。

项目成果

Genetically Encoded Cyclic Peptide Libraries: From Hit to Lead and Beyond.

基因编码环肽库：从热门到领先及其他。

• DOI: 10.1016/bs.mie.2018.09.020
• 发表时间: 2018
• 期刊: Methods in enzymology
• 作者: Valentine J