Organic Synthesis using Electrochemical Flow Reactors: Towards Sustainable Synthesis of High Value Chemicals

电化学可以用电流驱动的电子转移取代有毒、危险和昂贵的传统化学计量试剂，从而提供更清洁、更可持续的有机合成。我们的团队率先开发了用于实验室电合成的扩展路径长度的流动电池，并展示了它们在许多合成转化中的应用，包括氧化C-H功能化，醇氧化，选择C-C键形成以及氧化酯化和酰胺化过程。该项目涉及开发和发现新的电化学介导的合成方法，特别强调合成复杂分子的反应，包括药物中间体和天然产物。感兴趣的反应包括官能团转化和碳-碳键形成。后者将在复杂分子的合成中引起特别的兴趣。该项目是与我们的计划相关的光电，将学术和工业合作者。

Electrochemistry can provide enable cleaner and more sustainable organic syntheses by replacing conventional stoichiometric reagents, which may be toxic, hazardous and expensive, with electron transfer driven by the passage of electrical current. Our group has pioneered the development of extended path-length flow cells for laboratory electrosynthesis and demonstrated their application in a number of synthetic transformations including oxidative C-H functionalisations, alcohol oxidation, selected C-C bond formations and oxidative esterification and amidation processes.The project involves the development and discovery of new electrochemically-mediated synthetic methods, with particular emphasis on reactions of interest in the synthesis of complex molecules including pharmaceutical intermediates and natural products. Reactions of interest include functional group transformations and carbon-carbon bond formation. The latter will be of particular interest in the synthesis of complex molecules. The project is associated with our Programme grant Photo-Electro, will academic and industrial collaborators.