Pesticides And Parkinson's Disease

目的：在农业健康研究队列中进行帕金森病病例对照研究，以确定帕金森病风险增加是否与以下因素相关：农药暴露金属暴露暴露于星状诺卡氏菌，土壤微生物生活方式因素，包括饮食，吸烟，酒精和咖啡因使用参与异生物质代谢的基因多态性，或基因-环境相互作用。这项研究将是一项嵌套在农业健康研究中的病例对照研究，这是一项对82，000名持牌农药施用者及其配偶进行的大型队列研究。它将包括约160例病例和约480例对照。这项研究是第一个前瞻性地调查农药暴露与PD的关系，结合直接暴露测量与农药使用的详细生活史。这项研究将有很大的力量来解决这个问题，因为几乎所有的队列成员接触农药，虽然有相当大的差异，在队列内接触特定的化学品。我们已经制定了用于田间研究的方案和工具，并预计将于2001年9月开始招募受试者。

Aims: To conduct a case-control study of PD nested in the Agricultural Health Study cohort, in order to determine whether increased risk of PD is associated with: pesticide exposure metal exposure exposure to Nocardia asteroides, a soil microorganism lifestyle factors including diet, cigarette smoking, and alcohol and caffeine use polymorphisms in genes involved in xenobiotic metabolism, or gene-environment interactions Accomplishments: The study will be a case-control study nested within the Agricultural Health Study, a large cohort study of 82,000 licensed pesticide applicators and their spouses. It will include ~160 cases and ~480 controls. This study is the first to investigate the relationship of pesticide exposure to PD prospectively, combining direct exposure measurements with detailed life histories of pesticide use. The study will have great power to address this issue, since virtually all cohort members are exposed to pesticides, although there is considerable variability within the cohort in exposure to specific chemicals. We have developed protocols and instruments for use in the field study, and expect to begin recruiting subjects in September, 2001.