Neurochemical substrates of ethanol's locomotor effects

乙醇运动效应的神经化学底物

• 批准号: 6585010
• 负责人: Paul J Meyer
• 金额: $ 3.11万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-25 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6585010
• 关键词: amygdala; behavior test; chordate locomotion; dopamine; ethanol; experimental brain lesion; genetic models; glutamates; high performance liquid chromatography; injection /infusion; laboratory mouse; microdialysis; neurochemistry; neuropharmacology; neurophysiology; neurotransmitter transport; nucleus accumbens; predoctoral investigator; psychopharmacology; stereotaxic techniques; tegmentum

DESCRIPTION (provided by applicant): Understanding the effects of ethanol on simple behaviors such as locomotion provides a foundation for understanding more complex behaviors, such as ethanol self-administration and addiction. Further, studies with psychostimulants such as cocaine and amphetamine, and with ethanol as well, have revealed an overlap in the brain systems underlying both the locomotor and reinforcing effects of drugs. However, the neural substrates of ethanol-induced locomotion have not been as extensively studied. The goal of this proposal is to determine the neural bases for ethanol-induced locomotion. Brain lesions of areas within the mesolimbic dopamine system and the extended amygdala will be used to determine the neuroanatomical basis of the locomotor response to ethanol. In addition, microdialysis within these systems will be used to investigate the neurochemical events that are possibly correlated with this behavior. All of the experiments described in this proposal will utilize a genetic animal model of increased (FAST) and decreased (SLOW) sensitivity to ethanol's stimulant effects. This model of differential ethanol sensitivity is useful for examining behavioral and neurophysiological events that are genetically correlated to the locomotor response to ethanol.

描述（由申请人提供）： 了解乙醇对运动等简单行为的影响，为了解更复杂的行为（如乙醇自我管理和成瘾）提供了基础。此外，对可卡因和安非他明等精神兴奋剂以及乙醇的研究表明，药物的运动和强化作用在大脑系统中存在重叠。然而，乙醇诱导的运动的神经底物还没有得到广泛的研究。这项建议的目标是确定乙醇诱导运动的神经基础。中脑边缘多巴胺系统和扩展杏仁核内区域的脑损伤将用于确定运动的神经解剖学基础 对乙醇的反应。 此外，这些系统中的微透析将用于研究可能与这种行为相关的神经化学事件。本提案中描述的所有实验将利用对乙醇刺激作用的敏感性增加（快速）和降低（缓慢）的遗传动物模型。这个模型的差异乙醇敏感性是有用的研究行为和神经生理事件，遗传相关的运动响应乙醇。