Understanding Consent to Tissue Donation

描述：（改编自本申请）尽管组织 捐赠对公共卫生有更大的影响， 比实体器官捐赠更多的捐赠家庭和接受者，几乎没有研究 都是经过同意的捐赠组织提供心脏瓣膜 移植、皮肤移植和癌症中的截骨置换 患者它们被用于修复手术，治疗面部萎缩， 和许多其他程序。据估计，成千上万的病人 有资格捐献组织尽管如此，大多数对组织的要求 拒绝捐赠（同意率不高于35%）。最 重要的是，最近的争议提出了关于如何请求的问题， 用于组织捐赠这项为期4年的研究将直接检查组织 组织库工作人员使用的请求流程。我们将评估决定因素， 家人吗？捐赠组织的意愿，他们的信息需求，以及 充分的同意做法。对1 400个符合组织条件的家庭进行抽样调查 决策者和他们的组织工作人员申请者将被招募超过30- 月期间。病例将从13个国家的国家样本中随机抽取， 决定捐献家庭成员的家庭的组织库S 组织.本研究将从三个来源收集数据：1）符合条件的供体 病人？2）直接参与征求同意的请求者， 组织捐赠; 3）组织捐赠请求的录音。 这项研究将是第一个全面检查同意组织 捐赠。

DESCRIPTION: (Adapted from the Application) Despite the fact that tissue donation has greater public health implication and potentially affects many more donor families and recipients than solid organ donation, little research has been done on the consent process. Donated tissues provide heart valve replacements, skin grafts, and replacement of amputated bone in cancer patients. They are used in prosthetic surgery, treatment of facial wasting, and many other procedures. It is estimated that tens of thousands of patients are eligible to donate tissues. Nonetheless, most requests for tissue donation are refused (consent rates are no higher than 35%). Most importantly, recent controversies have raised questions about how requests are made for tissue donations. This 4-year study will directly examine the tissue request process used by Tissue Bank staff. We will assess the determinants of families? willingness to donate tissues, their informational needs, and the adequacy of consent practices. A sample of 1,400 tissue-eligible family decision makers and their tissue staff requesters will be recruited over a 30- month period. Cases will be randomly selected from a national sample from 13 tissue banks of families who made decisions about donating a family member?s tissue. This study will collect data from three sources: 1)donor-eligible patients? families; 2) requesters directly involved in asking for consent to tissue donation; 3) audiotaped recordings of the request for tissue donation. This study will be the first to comprehensively examine consent to tissue donation.