MRI OF COLLATERAL DEVELOPMENT IN THE HEART

心脏附带发育的 MRI

• 批准号: 6909611
• 负责人: Michael Jerosch-Herold
• 金额: $ 29.5万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-20 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6909611
• 关键词: bioimaging /biomedical imaging; blood flow measurement; blood volume; cardiovascular imaging /visualization; catecholamines; collateral circulation; coronary artery; coronary disorder; coronary occlusion /thrombosis; diagnosis design /evaluation; disease /disorder prevention /control; disease /disorder proneness /risk; dobutamine; heart circulation; heart contraction; heart disorder diagnosis; heart function; magnetic resonance imaging; myocardial infarction; myocardial ischemia /hypoxia; myocardium; noninvasive diagnosis; reperfusion; swine

DESCRIPTION (Adapted from Applicants Abstract): In ischemic heart disease the presence and extent of collateral circulation can prevent myocardial infarction, or at least limit the damage and reduce the size of infarcts. The objective of this proposal is to characterize the development of coronary collaterals in the heart with methods based on magnetic resonance imaging (MRI). MRI-based measures of collateral growth can define the functional capacity of collaterals to preserve myocardial blood flow and contractile function in regions at risk of infarction. This would be a significant advantage over current angiographic methods used to define the extent of collateral circulation in the heart. The proposed studies will also determine to what degree collateral development in heart translates into an increased capacity of the heart to prevent stress-induced ischemia. The studies will be carried out in an experimental animal model of collateral development with slow progressive occlusion of the left circumflex coronary artery ('ameroid constrictor' model). This animal model of collateral development approximates the progression of coronary artery disease as it occurs in humans. The proposed diagnostic MRI techniques for assessment of collateral blood flow in the heart may in the future allow improved prediction of outcome. Understanding how collateral growth can be followed non-invasively also means that one can assess more effectively new therapies that boost collateral development in the heart and which could markedly change the natural history of coronary artery disease.

描述（改编自《申请人摘要》）：在缺血性心脏病中

项目成果

Evaluation of myocardial volume heterogeneity during end-diastole and end-systole using cine MRI.

使用电影 MRI 评估舒张末期和收缩末期心肌体积异质性。

• DOI: 10.1081/jcmr-200036147
• 发表时间: 2004
• 期刊: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
• 作者: Swingen,Cory;Wang,Xiaoen;Jerosch-Herold,Michael
• 通讯作者: Jerosch-Herold,Michael

Feedback-assisted three-dimensional reconstruction of the left ventricle with MRI.

MRI 反馈辅助左心室三维重建。

• DOI: 10.1002/jmri.10290
• 发表时间: 2003
• 期刊: Journal of magnetic resonance imaging : JMRI.
• 作者: Swingen,CoryM;Seethamraju,RaviTeja;Jerosch-Herold,Michael
• 通讯作者: Jerosch-Herold,Michael

Assessment of collateralized myocardium with Cardiac Magnetic Resonance (CMR): transmural extent of infarction but not angiographic collateral vessel filling determines regional function and perfusion in collateral-dependent myocardium.

用心脏磁共振 (CMR) 评估侧支心肌：梗塞的透壁程度而非血管造影侧支血管充盈程度决定了侧支依赖性心肌的区域功能和灌注。

• DOI: 10.1016/j.ijcard.2006.08.036
• 发表时间: 2007
• 期刊: International journal of cardiology
• 影响因子: 3.5
• 作者: Muehling,Olaf;Jerosch-Herold,Michael;Cyran,Clemens;Huber,Armin;Schoenberg,Stefan;Reiser,Maximilian;Steinbeck,Gerhard;Nabauer,Michael
• 通讯作者: Nabauer,Michael