CHRONIC CORONARY OCCLUSION, EXERCISE TRAINING AND NO

慢性冠状动脉闭塞、运动训练和不

• 批准号: 6561410
• 负责人: JANET L PARKER
• 金额: $ 36万
• 依托单位: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-03 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6561410
• 关键词: angiogenesis; calcium flux; coronary occlusion /thrombosis; enzyme activity; exercise; fibroblast growth factor; gender difference; miniature swine; nitric oxide; superoxide dismutase; vascular endothelial growth factors; vascular endothelium

DESCRIPTION (Adapted from the applicant's abstract): Experiments of this proposal will examine how exercise training affects regulation of nitric oxide in coronary collaterals developed in response to chronic coronary occlusion in miniature swine. Five specific aims are proposed to systematically evaluate the effects of chronic exercise on various cellular biochemical events necessary for nitric oxide production: 1) Regulation of nitric oxide by changes in intracellular calcium will be examined; 2) the synergism between angiogenic growth factors, vascular endothelial growth factor (VEGF), and basic fibroblast growth factors (bFGF) and endothelial function will be examined; 3) regulation of superoxide dismutase will be evaluated to determine how production of superoxide radicals may relate to the bioavailability or stability of nitric oxide; 4) regulation of plasmalemmal caveolae microdomains will be examined; 5) these various aspects of control of nitric oxide (Specific Aims 1-4) will be compared between vessels derived from male and female animals. Results of these experiments will identify underlying endothelial mechanisms and sites of action which may implicate potential new therapeutic directions for optimizing blood flow to collateral-dependent myocardium distal to a chronic coronary artery occlusion in patients with coronary artery disease.

描述（改编自申请人摘要）：本实验