LEFT VENTRICULAR REMODELING IN AORTEC INSUFFICIENCY

描述(来自应用程序的逐字记录)： 导言。在过去的九年里，我们的实验室帮助开发和 验证以下所需的数学建模功能 临床评价心脏功能的方法是通过测定心脏的收缩和收缩功能 在体心肌舒张期应力-应变关系。这项建议 将把这些临床工具的应用扩展到全面的 与高血压相关的病理性左心室重构的评价 重度主动脉瓣关闭不全与病程、程度、持久性 以及发生的这种重塑逆转的预后意义 主动脉瓣置换术后(AVR)。Left的精确刻画 心室重塑及其逆转将直接与临床相关 大量具有临床意义的疾病过程。

DESCRIPTION (Verbatim from the application): Introduction. Over the last nine years, our laboratory has helped develop and validate the mathematical modeling capabilities that are necessary to clinically evaluate the function of the heart by assessing the systolic and diastolic stress-strain relationships of the in vivo myocardium. This proposal would extend the application of these clinical tools to the comprehensive evaluation of the pathological left ventricular (LV) remodeling associated with severe aortic valvular insufficiency and the time course, degree, durability and prognostic significance of the reversal of this remodeling that occurs after aortic valve replacement (AVR). The accurate characterization of left ventricular remodeling and its reversal would have direct clinical relevance to a large number of clinically significant disease processes.