LEFT VENTRICULAR REMODELING IN AORTEC INSUFFICIENCY

主动脉瓣功能不全的左心室重构

• 批准号: 6537813
• 负责人: MICHAEL K PASQUE
• 金额: $ 26.95万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-10 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6537813
• 关键词: aortic valve; aortic valve insufficiency; biomechanics; cardiovascular surgery; clinical research; dobutamine; heart catheterization; heart contraction; heart ventricle; human subject; human therapy evaluation; longitudinal human study; magnetic resonance imaging; mathematical model; medical implant science; muscle stress; myocardium; pathologic process; postoperative state; preoperative state; prognosis; prosthetic heart valve

DESCRIPTION (Verbatim from the application): Introduction. Over the last nine years, our laboratory has helped develop and validate the mathematical modeling capabilities that are necessary to clinically evaluate the function of the heart by assessing the systolic and diastolic stress-strain relationships of the in vivo myocardium. This proposal would extend the application of these clinical tools to the comprehensive evaluation of the pathological left ventricular (LV) remodeling associated with severe aortic valvular insufficiency and the time course, degree, durability and prognostic significance of the reversal of this remodeling that occurs after aortic valve replacement (AVR). The accurate characterization of left ventricular remodeling and its reversal would have direct clinical relevance to a large number of clinically significant disease processes.

描述（申请中的逐字记录）： 介绍。在过去的九年里，我们的实验室帮助开发和 验证必要的数学建模能力 通过评估收缩压和收缩压来临床评估心脏功能 体内心肌的舒张期应力-应变关系。这个提议 将这些临床工具的应用扩展到全面 评估与相关的病理性左心室（LV）重构 严重主动脉瓣关闭不全的时间、程度、持续时间 发生的这种重塑逆转的预后意义 主动脉瓣置换术（AVR）后。左边的准确表征 心室重塑及其逆转将具有直接的临床相关性 大量具有临床意义的疾病过程。