The Human Brain: Leveraging omic data to discover the genetics of matching energy supply and demand in health and disease

人脑：利用组学数据发现健康和疾病中能量供需匹配的遗传学

• 批准号: 2081652
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2081652
• 关键词: Human; Brain; Leveraging; omic; data

The energy demands of the brain are high and evolutionary studies indicate that emergence of higher cognitive function in humans is associated with shifting energy metabolism. Despite a key role for tightly co-regulated mitochondrial and nuclear processes to satisfy high-energy demands, the genetics and functional mechanisms linking the nuclear and mitochondrial genomes remain understudied in brain. This project aims to uncover how genetic variation modulates the mitochondrial transcriptome in different brain regions, to understand the evolutionary trajectory of identified genetic variation associated with the development of the human brain, and the importance of these processes in human ageing and disease.

大脑的能量需求很高，进化研究表明，人类更高认知功能的出现与能量代谢的变化有关。尽管紧密共调控的线粒体和核过程在满足高能量需求方面发挥着关键作用，但连接核和线粒体基因组的遗传学和功能机制在大脑中仍然研究不足。该项目旨在揭示遗传变异如何调节不同大脑区域的线粒体转录组，了解与人类大脑发育相关的已识别遗传变异的进化轨迹，以及这些过程在人类衰老和疾病中的重要性。