Tool use and the neural representation of arm position

工具使用和手臂位置的神经表征

• 批准号: 6540497
• 负责人: DYLAN Francis COOKE
• 金额: $ 3.76万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6540497
• 关键词: Macaca fascicularis; behavioral /social science research tag; body image; cell population study; experience; imagery; limb movement; microelectrodes; neural information processing; neural plasticity; neurons; neuropsychological tests; neuropsychology; operant conditionings; parietal lobe /cortex; proprioception /kinesthesia; prosthesis; psychophysiology; single cell analysis; space perception; visual perception; visual stimulus

DESCRIPTION(adapted from applicant?s abstract): The aim of the proposed experiment is to test how the use of tools modifies the neuronal representation of arm position in monkey parietal area 5. The brain contains a representation of the body, and external objects such as tools and prosthetic limbs can be incorporated into this body Image. Many neurons in area 5 respond to the static position of the arm. How are the responses of these neurons modified by the experience of using a tool? First, a neurons sensitivity to arm position will be tested In the dark during a fixation task. Next, the monkey will perform a tool use task in the light requiring him to touch targets with the end of the tool. The tool will be configured to the left of the monkey?s arm. Alter this tool use experience, the neuron?s sensitivity to arm position will be re-tested and the two arm position tuning curves, observed before and after tool use, will be compared. We hypothesize that after the monkey uses the leftward-bent tool, the neuron may begin to encode the offset position of the tool. In this case, the neuron?s tuning curve for arm position should be offset to the right. Neurons will also be tested similarly with a rightward-bent tool. A result of this type would indicate that the tool had been incorporated into the neuronal representation of the body as an extension of the arm. An understanding of how the neuronal representation of the body Image changes with experience may in the future contribute to therapies for stroke patients with parietal damage and amputees with phantom pain.

描述（改编自申请人？（摘要）：建议的目的 实验是为了测试工具的使用如何改变神经元的表征 在猴子顶叶5区的手臂位置。大脑中有一个表征 和外部物体，如工具和假肢， 融入到这个身体形象中。5区的许多神经元对静电有反应 手臂的位置。这些神经元的反应是如何被 使用工具的经验？首先，神经元对手臂位置的敏感性将 在黑暗中进行测试。接下来，猴子将表演一个 工具使用任务中的光要求他接触目标的结束 工具.将工具配置到猴子的左边？的手臂。改变这个 工具使用经验，神经元？的灵敏度手臂的位置将重新测试 以及在工具使用之前和之后观察的两个臂位置调谐曲线， 将被比较。我们假设在猴子使用左弯后 工具，则神经元可以开始对工具的偏移位置进行编码。在这 案例，神经元？手臂位置的调谐曲线应该向右偏移。 神经元也将用向右弯曲的工具进行类似的测试。的结果 这种类型将表明该工具已被纳入神经元 将身体表现为手臂的延伸。理解如何 身体意象的神经元表征随着经验的变化而变化， 未来有助于治疗脑顶叶损伤的中风患者， 有幻痛的截肢者