Human Motor Unit Discharge Variability

人体运动单位放电变异性

• 批准号: 6446406
• 负责人: CHRISTOPHER A KNIGHT
• 金额: $ 1.16万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-12 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6446406
• 关键词: action potentials; age difference; aging; biological signal transduction; biomechanics; clinical research; computer human interaction; electrical measurement; electrodes; electrophysiology; human old age (65+); human subject; morphology; motor neurons; muscle cells; muscle contraction; neurophysiology; predoctoral investigator; psychomotor function; sensory feedback; smooth muscle; statistics /biometry; striated muscles; young adult human (21-34)

DESCRIPTION: (provided by applicant) Neuromuscular disorders such as stroke or multiple sclerosis have consequences that affect the control of muscular force. Even though the origin of many disorders may be centrally determined, the fundamental unit of force control, the motor unit, will reflect the consequences. There is abundant information on control strategies such as the rules governing the recruitment of motor units. What we do not understand, however, is the nature and meaning of variability that exists within motor unit discharge behavior. The fluctuations in motor unit discharge during sustained muscular contractions have received very little attention compared to the study of variability in settings such as cardiovascular research. The mere appearance of random noise in a signal has often resulted in premature conclusions. However, it may be the case that conditions such as pathological tremor result from structure that exists within motor unit discharge fluctuations. Indeed, pilot data indicate that non-random structure is inherent in these fluctuations and I wish to further explore the characteristics and meaning of motor unit discharge variability. Motor unit discharge variability will be compared among muscles that are designed for precision control or gross force production. The effects of muscular force and sensory manipulations will be investigated in both muscle types. Each of these experimental conditions will be performed by older and young individuals to evaluate the impact of known age-related changes in motor unit morphology on motor unit discharge variability. The proposed research will systematically investigate analytical techniques that are new to motor unit research. The information content of such techniques will be compared to that provided by established analytical methods. Like the research on heart rate variability, I hope to provide effective diagnostic tools for evaluating neuromuscular health.

描述：（由申请人提供）神经肌肉疾病，如中风或

项目成果

Enhanced motor unit rate coding with improvements in a force-matching task.

通过力匹配任务的改进增强了运动单位速率编码。

• DOI: 10.1016/j.jelekin.2004.04.005
• 发表时间: 2004
• 期刊: Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology.
• 作者: Knight,ChristopherA;Kamen,Gary
• 通讯作者: Kamen,Gary