Inorganic Ion Exchanger for use in 82Sr/82Rb Separations

用于 82Sr/82Rb 分离的无机离子交换剂

• 批准号: 6529862
• 负责人: HARIPRASAD GALI
• 金额: $ 39.75万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6529862
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; ion exchange chromatography; physical separation; positron emission tomography; radiochemistry; radionuclides; rubidium; strontium; technology /technique development; titanium

DESCRIPTION (Provided by Applicant): 82Rb, a positron-emitting radionuclide that finds extensive use in Positron Emission Tomography (PET) for heart imaging, is supplied to physicians in the form of a generator. 82Sr is immobilized on an ion exchange column and 82Rb eluted when required. Hydrous tin dioxide is the current ion exchange material of choice, but advances in ion exchange materials have meant that new, more suitable materials are now available. The parent 82Sr is an expensive isotope, and is produced by the proton irradiation of target materials (e.g. molybdenum) followed by extensive processing to isolate pure 82Sr. This SBIR Phase II project will use sodium nonatitanate, an advanced strontium-selective ion exchange material, to simplify 82Sr isolation from targets, and as a sorbet for 82Sr in 82Rb generators. New, more efficient target processing techniques will be developed, leading to decreased target processing times, decreased waste generation, improved 82Sr yield, and thus a decrease in the cost of the 82Sr product. 82Rb generator life will be extended, and a decrease in breakthrough of 82Sr and 85Sr obtained. These two aspects of the project will lower the cost of 82Rb PET and decrease patient exposure to 85Sr and 82Sr. PROPOSED COMMERCIAL APPLICATION: The improved generator will be compatible with existing automated 82Rb infusion systems, leading to widespread application at medical centers currently administering 82Rb. Improved target processing flowsheets will also aid in the seperation of other isotopes from targets, e.g. 68Ge, which have medical applications.

描述(申请人提供)：82Rb，一种发射正电子的放射性核素，广泛用于心脏正电子发射断层扫描(PET) 成像，以发电机的形式提供给医生。82锶是 固定在离子交换柱上，82Rb在需要时洗脱。含水的 二氧化锡是目前离子交换材料的首选，但在离子交换方面取得了进展 交换材料意味着现在新的、更合适的材料 可用。母体82Sr是一种昂贵的同位素，由 质子辐照靶材料(如钼)，随后广泛 高纯度~(82)锶的分离工艺。 这个SBIR二期项目将使用一种先进的 锶选择性离子交换材料，以简化从 靶，并作为82Rb发生器中82Sr的冰糕。全新的、更高效的 将发展目标处理技术，导致目标减少 处理时间，减少废物产生，提高82sr产率，从而 降低了82SR产品的成本。82Rb发电机寿命将延长， ~(82)Sr和~(85)Sr的穿透率降低。这两个方面 该项目将降低82Rb PET的成本，并减少患者对 85锶和82sr。 建议的商业应用： 改进后的发生器将与现有的自动82Rb输液系统兼容，从而在目前管理82Rb的医疗中心得到广泛应用。改进的靶处理流程还将有助于从具有医疗应用的靶中分离其他同位素，例如68Ge。