TREATMENT OF DEPRESSION IN PARENTS--IMPACT ON CHILDREN

描述（改编自申请人的摘要）：拟议的项目将 研究治疗父母抑郁症对儿童 社会情绪调整 该项目将与两个新的接口 资助的NIMH治疗研究，诊断为重度抑郁症的成年人 disorder. 第一个是在范德比尔特进行的两个地点的研究 大学（PI，Steve Hollon，Ph.D.）在宾夕法尼亚大学 (PI，Rob DeRubeis，Ph.D.）。第二项研究将在哥伦比亚大学进行， 华盛顿（PI，Neil Jacobson，Ph.D.）。在这三个地点，640名成年人 将接受认知治疗、药物治疗或安慰剂（加上 UW的行为细胞）。 根据去年收集的初步数据， 四个月后，我们估计大约25%的患者会有孩子。 年龄在8到16岁之间，并同意参加。 这些初步 数据提供了项目可行性和可接受性的证据， 并显示，目前抑郁的父母的目标儿童 出现严重的症状和功能障碍 拟议 项目将涉及一个指数儿童的全面评估， 关于精神病理学和功能时，父母进入 治疗研究，并再次在2，4，8，12，18和24个月。 比较组 父母终身没有精神病和医疗疾病的儿童， 疾病也将包括在内。 本研究的主要目的是：（a）研究 减少父母的抑郁和儿童功能的变化;（B） 探索这些变化的可能媒介，包括父母-孩子 关系、婚姻功能、压力源和认知;以及（c） 测试儿童适应的变化，假设的调解人， 父母和孩子之间的关系症状不同的功能， 父母接受的治疗。 数据分析将涉及 传统的重复测量多变量方差分析方法 以及一种更普遍和创新的个体生长曲线方法 使用协方差结构分析建模。 这项研究代表了一个真正的 这是一个独特的机会，可以进一步加深我们对联系的理论理解 父母和孩子之间的精神病理学，可以作为指导， 制定针对高危人群的预防干预措施。

DESCRIPTION (Adapted from applicant's abstract): The proposed project will study the impact of treating parental depression on children's socio-emotional adjustment. This project will interface with two newly funded NIMH treatment studies of adults diagnosed with major depressive disorder. The first is a two-site study being conducted at Vanderbilt University (PI, Steve Hollon, Ph.D.) and at the University of Pennsylvania (PI, Rob DeRubeis, Ph.D.). The second study will be at the University of Washington (PI, Neil Jacobson, Ph.D.). Across the three sites, 640 adults will receive cognitive therapy, pharmacotherapy, or placebo (plus a behavioral cell at UW). Based on preliminary data collected in the last four months, we estimate that about 25% of the patients will have children between 8 and 16 years old and will agree to participate. These preliminary data provide evidence of the feasibility and acceptability of the project, and showed that the targeted children of currently depressed parents were experiencing significant levels of symptoms and dysfunction. The proposed project will involve a comprehensive assessment of an index child with regard to psychopathology and functioning at the time the parent enters the treatment study and again at 2,4,8,12,18, and 24 months. A comparison group of children whose parents are lifetime-free of psychiatric and medical disorders also will be included. The primary aims of the study are: (a) to examine the relation between decreases in parent's depression and changes in children's functioning;(b) to explore possible mediators of these changes including the parent-child relationship, marital functioning, stressors, and cognitions; and (c) to test whether changes in child adaptation, the hypothesized mediators, and the relation between parent and child symptoms differ as a function of the type of treatment the parent received. Data analysis will involve traditional methods of repeated measures multivariate analyses of variance and a more general and innovative approach of individual growth curve modeling using covariance structure analysis. This study represents a truly unique opportunity to further our theoretical understanding of the link between parent and child psychopathology that can serve as a guide for the development of preventive interventions for high risk populations.