Growth and heredity of protocells at the origin of life under simulated hydrothermal conditions

模拟水热条件下生命起源的原始细胞的生长和遗传

• 批准号: 2089390
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2089390
• 关键词: Growth; heredity; protocells; origin; life

Autotrophic metabolism in bacteria and archaea is driven by electrochemical ion gradients across the plasma membrane to fix CO2 as organic molecules. Computational modelling and experimental work suggest that a rudimentary form of membrane heredity could have driven growth of protocells under alkaline hydrothermal conditions. This project will develop the initial computational modelling to consider the introduction of an energy currency (e.g. acetyl phosphate) in this setting, specifically analysing the prebiotic synthesis of amino acids, sugars and nucleotides. The project will test the model's predictions in the lab, using microfluidic chips coupled to FTIR, Raman, GC-MS, LC-MS and HPLC.

细菌和古细菌中的自养代谢是由跨质膜的电化学离子梯度驱动的，以将CO2固定为有机分子。计算模型和实验工作表明，在碱性水热条件下，膜遗传的基本形式可能驱动原始细胞的生长。该项目将开发初始计算模型，以考虑在这种环境中引入能量货币（例如乙酰磷酸），特别是分析氨基酸，糖和核苷酸的益生元合成。该项目将在实验室中测试该模型的预测，使用微流控芯片耦合FTIR，拉曼，GC-MS，LC-MS和HPLC。

项目成果

Prebiotic Synthesis of Aspartate Using Life's Metabolism as a Guide.

使用生命代谢作为指导的天冬氨酸的益生元合成。

• DOI: 10.3390/life13051177
• 发表时间: 2023-05-12
• 期刊: Life (Basel, Switzerland)

Life as a Guide to Its Own Origins

生命作为其自身起源的指南

• DOI: 10.1146/annurev-ecolsys-110421-101509
• 发表时间: 2023
• 期刊: Annual Review of Ecology, Evolution, and Systematics
• 作者: Harrison S

Spontaneous assembly of redox-active iron-sulfur clusters at low concentrations of cysteine.

• DOI: 10.1038/s41467-021-26158-2
• 发表时间: 2021-10-11
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Jordan SF;Ioannou I;Rammu H;Halpern A;Bogart LK;Ahn M;Vasiliadou R;Christodoulou J;Maréchal A;Lane N
• 通讯作者: Lane N